Etomidate–propofol mixture versus propofol for anesthesia in older adults having abdominal surgery

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Researchers will compare a mixture of etomidate and propofol to propofol alone for total intravenous anesthesia in older adults having elective abdominal operations. Eligible participants (ASA I–III, BMI 18–28) who expect 1–4 hours of anesthesia will receive one of the two anesthesia regimens during surgery and will be monitored closely. The study will record intraoperative hypotension, perioperative cardiovascular events, and measures of adrenal cortical function in the 48 hours after surgery. Safety outcomes, awakening times, and postoperative complications will be compared between the two groups.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* ASA Ⅰ\~Ⅲ;
* BMI was 18-28 kg/m2;
* For elective abdominal surgery under intravenous general anesthesia;
* The expected duration of anesthesia was 1 to 4 hours.

Exclusion Criteria:

* Septic shock and multiple organ failure diagnosed within 14 days;
* Hyperkalemia (serum potassium \>5.5mmol/L) within 48 hours;
* Stroke or transient ischemic attack within 3 months;
* Patients with unstable angina pectoris or myocardial infarction within 3 months; Arrhythmia requiring treatment was not treated or treatment did not meet expectations;
* Patients with preoperative diagnosed diabetes mellitus and uncontrolled blood glucose; Diabetic complications were diagnosed before surgery, including diabetic ketoacidosis, hyperosmolar coma, diabetes-related infection, diabetic nephropathy, retinopathy, diabetic cardiomyopathy, diabetic neuropathy, diabetic foot, etc.
* Severe liver and renal dysfunction;
* Liver surgery, renal surgery, adrenal surgery, day surgery;
* Resting blood pressure ≥180/110 mmHg (2020 ISH hypertension guideline ≥ grade 3 hypertension); Or systolic blood pressure \<90mmHg or mean blood pressure \<65mmHg.
* Taking corticosteroids or other immunosuppressants for more than 10 days within 6 months or having a history of adrenal cortex suppression or immune system diseases;

Where it's running

• Tongji hospital
  Wuhan, Hubei, China Recruiting

Study contacts

• Principal investigator: Shiyong Li — Department of Anesthesiology of Tongji Hospital
• Study coordinator: Shiyong Li
• Email: shiyongli@hust.edu.cn
• Phone: 02783665480

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.