Ethyl chloride spray to reduce injection pain during Mohs surgery
Ethyl Chloride Spray to Reduce Pain From Local Anesthesia During Mohs Micrographic Surgery: A Randomized Clinical Trial
This will test whether spraying ethyl chloride on the skin before local anesthesia reduces injection pain for patients having Mohs micrographic surgery with Dr. Daniel Eisen at UC Davis.
Quick facts
| Phase | Early Phase 1 |
|---|---|
| Study type | Interventional |
| Enrollment | 80 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | University of California, Davis Academic / other |
| Locations | 1 site (Sacramento, California) |
| Trial ID | NCT06920381 on ClinicalTrials.gov |
What this trial studies
This early-phase interventional study will try using Gebauer's ethyl chloride topical spray applied immediately before local anesthetic injections to reduce pain during Mohs micrographic surgery. Enrollment is limited to patients scheduled with Dr. Daniel Eisen at UC Davis whose pre-operative tumor measures at least 1.5 cm. The spray is applied at the procedure site prior to injections and patient-reported injection pain will be recorded to determine any difference. Patients with cold-sensitive skin disorders, periocular treatment sites, or recent anxiolytic use are excluded and the work is conducted at a single center in Sacramento, California.
Who should consider this trial
Good fit: Ideal candidates are patients scheduled for Mohs micrographic surgery with Dr. Daniel Eisen at UC Davis whose pre-op tumor is at least 1.5 cm and who do not have cold-related skin disorders or recent anxiolytic use.
Not a fit: Patients with tumors smaller than 1.5 cm, lesions around the eyes, cold-sensitive skin disorders, or who have taken anxiolytics within the past four hours are excluded and unlikely to receive benefit from this protocol.
Why it matters
Potential benefit: If successful, the spray could reduce injection pain and related anxiety during Mohs procedures, improving patient comfort and the clinic experience.
How similar studies have performed: Pre-cooling and cryotherapy methods have shown some benefit in other injection-pain settings, but ethyl chloride specifically has limited published trial data and is relatively untested in Mohs surgery.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * All patients scheduled for MMS with Dr. Daniel Eisen at UC Davis Health Department of Dermatology (3301 C St #1300-1400, Sacramento, CA 95816) * Pre-op tumor size at least 1.5 cm (measured on day of procedure) Exclusion Criteria: * Skin disorders related to cold temperatures (i.e. cryoglobulinemia) * Anxiolytic medication within past 4 hours * Treatment sites around the eyes * Pre-op tumor size smaller than 1.5 cm (measured on day of procedure)
Where this trial is running
Sacramento, California
- UC Davis Dermatology — Sacramento, California, United States (Recruiting)
Study contacts
- Study coordinator: Salsala Nasim, BS
- Email: sanasim@ucdavis.edu
- Phone: 916-551-2636
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.