Ethnic differences in S100B blood levels among healthy adults in Guadeloupe
Official title: Ethnic Specificities of S100B Protein Blood Level in Guadeloupe: Cross-sectional Study in Healthy Subjects
Run by Centre Hospitalier Universitaire de la Guadeloupe · NCT06998381 · Data updated 2026-11-12
This project will test whether normal S100B protein blood levels differ by skin phenotype in healthy adults living and working in Guadeloupe.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years to 65 Years |
| Sex | All |
| Enrollment | 200 (estimated) |
| Sponsor | Centre Hospitalier Universitaire de la Guadeloupe Academic / other |
| Locations | 2 sites (Basse-Terre and 1 other locations) |
| Status | Recruiting |
| Started | February 1, 2023 |
| Main results expected | August 1, 2025 |
| Study ends | August 1, 2025 |
| Registry record updated | May 31, 2025 |
| Trial ID | NCT06998381 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Healthy adults 18–65 who work at the University Hospital of Guadeloupe or the Hospital of Basse‑Terre, can state their ethnic origin and skin phototype, have social security coverage, and give written informed consent.
✕Probably not a fit
People with neurological disease, a personal history of melanoma, on anticoagulant therapy, under legal protection, outside the age range, or not local hospital staff are unlikely to benefit from participation.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This cross-sectional study will measure S100B protein concentrations in blood samples from healthy adult hospital staff in Guadeloupe and record self-identified ethnic origin and skin phototype. Participants aged 18–65 without neurological disease, melanoma history, or anticoagulant use will be enrolled and sampled at local hospital sites. The study will compare baseline S100B distributions across phenotype groups to see if the commonly used 0.1 μg/L threshold is appropriate locally. Results aim to clarify physiological variability that could affect use of S100B to guide head CT decisions after minor head injury.
Why it matters
Potential benefit: If successful, the findings could support ethnicity‑ or skin‑phototype‑adjusted S100B thresholds that reduce unnecessary head CT scans in Guadeloupe while maintaining patient safety.
How similar studies have gone: S100B has been guideline‑endorsed to reduce CT use in minor TBI and a small prior study reported higher baseline S100B in individuals of Black phenotype, but larger confirmatory studies are lacking.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria : * Hospital staff of the University Hospital of Guadeloupe or the Hospital of Basse-Terre * Age between 18 and 65 years * Individuals willing to specify their ethnic origin and skin phototype * Individuals affiliated with or beneficiaries of a social security scheme * Informed individuals who have given their voluntary, informed, and written consent Exclusion Criteria : * Individuals on anticoagulant therapy * Individuals with a personal history of neurological disease * Individuals with a personal history of melanoma * Refusal to participate * Individuals under guardianship, curatorship, or legal protection
Where it's running
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CH de la Basse-Terre
Basse-Terre, Guadeloupe Recruiting -
Chu de La Guadeloupe
Pointe-à-Pitre, Guadeloupe Recruiting
Study contacts
- Principal investigator: Delphine Delta, MD — CHU de la Guadeloupe
- Study coordinator: Valérie Hamony Soter
- Email: valerie.soter@chu-guadeloupe.fr
- Phone: +590590934677
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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Measuring S100B Protein Levels in Newborns After Intrauterine Blood Transfusions for Fetal Anemia
This study is testing if measuring a specific protein in the blood of newborns who received blood transfusions before birth can help predict the risk of brain problems later on.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.