Clinical trial Recruiting at 1 site Observational Ages 18 to 41 Women only

Ethanol sclerotherapy for treating ovarian endometriomas

Official title: Endometrioma Ethanol Sclerotherapy and Its Effect on Ovarian Function and Fertility Treatment Outcome - Prospective Cohort Study Protocol

Run by Hillel Yaffe Medical Center · NCT06971458 · Data updated 2026-11-12

This study tests if a treatment using ultrasound-guided ethanol can help women with painful ovarian cysts shrink them and reduce their symptoms.

Quick facts

Study typeObservational
Ages18 Years to 41 Years
SexWomen only
Enrollment120 (estimated)
SponsorHillel Yaffe Medical Center
Government
Locations1 site (Hadera)
StatusRecruiting
StartedAugust 9, 2022
Main results expectedDecember 31, 2027
Study endsDecember 31, 2027
Registry record updatedMay 14, 2025
Trial IDNCT06971458 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates for this study are women with ovarian endometriomas measuring between 25-100 mm.

Probably not a fit

Patients with infertility due to other causes, such as sperm disorders or uterine abnormalities, may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study investigates the effectiveness of ultrasonography-guided ethanol sclerotherapy as a treatment for ovarian endometriomas, which are cystic masses associated with pelvic pain and infertility. The approach aims to destroy the inner epithelial lining of the cyst, leading to inflammation and fibrosis, ultimately resulting in cyst regression while minimizing damage to surrounding ovarian tissue. The study will include women with endometriomas measuring 25-100 mm in diameter and will exclude those with other infertility causes.

Why it matters

Potential benefit: If successful, this treatment could provide a less invasive option for women suffering from endometriomas, potentially improving fertility outcomes and reducing pain.

How similar studies have gone: While there are no established guidelines for this approach, the use of sclerotherapy for endometriomas is a novel method that has not been widely tested in clinical settings.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

A woman with endometrioma with a diameter of 25-100 mm

Exclusion Criteria:

* Other causes of infertility (sperm disorder, ovulation disorder, uterine disorder, mechanical factor, poor ovarian reserve)

Where it's running

  • Hillel Yaffe Medical Center
    Hadera, Israel
    Recruiting

Study contacts

  • Principal investigator: Einat Shalom-Paz, Prof — Hillel Yaffe Medical Center
  • Study coordinator: Einat Shalom-Paz, Prof
  • Email: EINATS@hymc.gov.il
  • Phone: +972-4-7744750

Similar studies

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How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.