Ethanol sclerotherapy for treating ovarian endometriomas
Official title: Endometrioma Ethanol Sclerotherapy and Its Effect on Ovarian Function and Fertility Treatment Outcome - Prospective Cohort Study Protocol
Run by Hillel Yaffe Medical Center · NCT06971458 · Data updated 2026-11-12
This study tests if a treatment using ultrasound-guided ethanol can help women with painful ovarian cysts shrink them and reduce their symptoms.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years to 41 Years |
| Sex | Women only |
| Enrollment | 120 (estimated) |
| Sponsor | Hillel Yaffe Medical Center Government |
| Locations | 1 site (Hadera) |
| Status | Recruiting |
| Started | August 9, 2022 |
| Main results expected | December 31, 2027 |
| Study ends | December 31, 2027 |
| Registry record updated | May 14, 2025 |
| Trial ID | NCT06971458 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are women with ovarian endometriomas measuring between 25-100 mm.
✕Probably not a fit
Patients with infertility due to other causes, such as sperm disorders or uterine abnormalities, may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study investigates the effectiveness of ultrasonography-guided ethanol sclerotherapy as a treatment for ovarian endometriomas, which are cystic masses associated with pelvic pain and infertility. The approach aims to destroy the inner epithelial lining of the cyst, leading to inflammation and fibrosis, ultimately resulting in cyst regression while minimizing damage to surrounding ovarian tissue. The study will include women with endometriomas measuring 25-100 mm in diameter and will exclude those with other infertility causes.
Why it matters
Potential benefit: If successful, this treatment could provide a less invasive option for women suffering from endometriomas, potentially improving fertility outcomes and reducing pain.
How similar studies have gone: While there are no established guidelines for this approach, the use of sclerotherapy for endometriomas is a novel method that has not been widely tested in clinical settings.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: A woman with endometrioma with a diameter of 25-100 mm Exclusion Criteria: * Other causes of infertility (sperm disorder, ovulation disorder, uterine disorder, mechanical factor, poor ovarian reserve)
Where it's running
-
Hillel Yaffe Medical Center
Hadera, Israel Recruiting
Study contacts
- Principal investigator: Einat Shalom-Paz, Prof — Hillel Yaffe Medical Center
- Study coordinator: Einat Shalom-Paz, Prof
- Email: EINATS@hymc.gov.il
- Phone: +972-4-7744750
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
G-CSF for DOR in women undergoing IVF
This trial tests whether G-CSF shots can improve IVF outcomes for women with diminished ovarian reserve.
-
Dual Trigger vs HCG Trigger for Final Maturation in Normal Responders
In normal responders undergoing ICSI cycles, this study tests whether using a dual trigger (GnRH agonist plus hCG) improves outcomes compared with the standard hCG trigger.
-
Pentoxifylline to improve uterine lining and frozen embryo transfer outcomes
This trial sees if giving pentoxifylline alongside standard estradiol helps women with good-quality day‑5 frozen embryos get a thicker uterine lining and better frozen embryo transfer success.
-
Tadalafil to increase uterine lining and improve frozen embryo transfer success
This test sees if adding daily tadalafil to standard estrogen helps women with unexplained infertility using good-quality day‑5 frozen embryos get a thicker uterine lining and better transfer outcomes.
-
Aromatherapy to support mental health in women undergoing IVF
This will test whether inhaling lavender oil twice daily can reduce anxiety, stress, and depression and improve quality of life for women awaiting IVF.
-
Non-invasive embryo genetic screening in egg donation cycles
This will test whether a non-invasive genetic test of the embryo culture fluid can predict implantation and pregnancy outcomes for people receiving donated eggs.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.