Erector spinae plane block for septic patients with gastrointestinal injury

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial investigates the effectiveness of the erector spinae plane block in improving organ dysfunction in septic patients suffering from acute gastrointestinal injury. It is a multicenter, parallel-group, open-label, randomized controlled trial designed to assess the impact of this intervention on patient outcomes. The study aims to build on previous findings that suggested this technique may enhance recovery in similar patient populations. Participants will be monitored for improvements in organ function during their ICU stay.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Septic patients with acute gastrointestinal injury grade II or III;
* Age over 18 years;
* Expected to stay in the ICU for at least 3 days or longer;

Exclusion Criteria:

* Mean arterial pressure less than 65 mmHg after fluid resuscitation, or requirement for an intravenous norepinephrine dose of greater than 0.5 µg/kg/min to maintain a normal mean arterial pressure;
* Heart rates less than 50 beats/min, or concomitant with moderate-to-severe atrioventricular block without a pacemaker;
* Contraindications for erector spinae plane blocks, including infection of the puncture site, spinal diseases or immobilization;
* Primary gastrointestinal disorders requiring a surgical procedure, such as mechanical intestinal obstruction, massive gastrointestinal hemorrhage, and gastrointestinal perforation;
* Gastrointestinal operation within one week before enrollment;
* Neuromuscular disorders;
* Coagulation abnormalities：activated prothrombin time or prothrombin time is prolonged with 2 folds, or platelet count less than 50×109/L;
* End-stage malignant tumor or cachexia;
* History of allergy to amide anesthetics;
* Known pregnancy;

Where it's running

• Department of Intensive Care Medicine of Zhujiang Hospital,Southern Medical University
  Guangzhou, Guangdong, China Recruiting

Study contacts

• Principal investigator: Jing Cai — Department of Intensive Care Medicine, Zhujiang Hospital, Southern Medical University
• Study coordinator: Jing Cai, MD
• Email: caijing78@hotmail.com
• Phone: +86-02062782927

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.