Erector spinae plane block during laparoscopic colorectal cancer surgery
Erector Spinae Plane Block in Laparoscopic Colorectal Cancer Surgery: Effects on Renal Blood Flow and Kidney Function
This study will try giving an erector spinae plane block during laparoscopic colorectal cancer surgery to see if it helps protect kidney blood flow and function in adult patients.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 60 (estimated) |
| Ages | 18 Years to 75 Years |
| Sex | All |
| Sponsor | Kayseri City Hospital Government |
| Locations | 1 site (Kayseri) |
| Trial ID | NCT07297433 on ClinicalTrials.gov |
What this trial studies
This randomized, controlled study at Kayseri City Hospital will enroll 60 adults undergoing planned laparoscopic colorectal cancer surgery and assign 30 patients to receive an erector spinae plane (ESP) block and 30 to a control group with no block. Intraoperative renal blood flow will be monitored using near-infrared spectroscopy alongside standard invasive monitoring, and postoperative renal function will be tracked using NGAL, serum creatinine, and eGFR. The ESP block will be performed under ultrasound guidance after anesthesia induction, and group allocation will be done by sealed envelope randomization. The trial emphasizes physiological and biomarker endpoints to detect effects on renal perfusion and function rather than long-term clinical outcomes.
Who should consider this trial
Good fit: Adults aged 35–75 scheduled for elective laparoscopic colorectal cancer surgery who have no infection at the injection site, no bleeding or clotting disorders, no history of local anesthetic allergy, and BMI under 30 are ideal candidates.
Not a fit: Patients with BMI ≥30, active systemic or injection-site infection, bleeding/clotting disorders, local anesthetic allergy, or those outside the 35–75 age range are excluded and unlikely to receive benefit from this protocol.
Why it matters
Potential benefit: If successful, adding an ESP block could reduce intraoperative drops in renal blood flow and lower the risk of postoperative kidney injury.
How similar studies have performed: ESP blocks are commonly used and accepted for perioperative analgesia, but using them specifically to improve intraoperative renal perfusion and postoperative renal biomarkers is largely novel with limited prior data.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age: 35-75 years old * Colorectal cancer surgery must be planned by a physician * No infection in the injection site * No history of any disease related to clotting or bleeding time * The patient must be a volunteer * No history of local anesthetic allergy Exclusion Criteria: * Being under 18 years of age * Having a systemic infection or infection at the injection site * Having any disease related to bleeding time and clotting * Having a history of local anesthetic allergy * Patient refusal (ESPB for analgesic purposes) * Patients with a Body Mass Index (BMI) of 30 or above
Where this trial is running
Kayseri
- Kayseri Şehir Hastanesi — Kayseri, Turkey (Türkiye) (Recruiting)
Study contacts
- Principal investigator: Günhan Gökahmetoğlu — Kayseri City Hospital
- Study coordinator: Arif Enes Koyuncu
- Email: arifenesk95@gmail.com
- Phone: +905062875795
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.