Epidural spinal cord stimulation for lower limb issues in a rare genetic condition

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial investigates the use of spinal cord stimulation (SCS) to improve lower limb motor function in patients with adrenomyeloneuropathy (AMN), a rare genetic disorder. The study involves implanting a thin electrode into the epidural space to deliver electrical pulses that stimulate sensory neurons, potentially alleviating symptoms such as muscle weakness and impaired mobility. Participants must meet specific diagnostic criteria and undergo assessments to ensure they can communicate and complete tests independently. The trial aims to provide a new therapeutic approach for a condition that currently lacks effective treatment options.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Conforming to the diagnostic criteria of AMN, with a definite genetic testing report, and complicated by lower limb motor function disorders;
* Capable of normal communication and able to complete scale tests independently (as determined by on-site scale tests);
* Willing to participate in this study after giving informed consent;
* The muscle tone of the patient's bilateral lower extremities was elevated.

Exclusion Criteria:

* Other inherited diseases;
* Other severe central nervous system diseases;
* History of brain surgery;
* Psychiatric and psychological diseases such as depression and anxiety;
* The presence of metallic foreign bodies or prostheses (such as cardiac pacemakers, insulin pumps) in the body, claustrophobia, and other contraindications for MRI;
* Informed consent was not obtained;
* Unable to tolerate MRI-related examinations;
* Received anticoagulant, antispasmodic or antiepileptic drug therapies throughout the entire study period;
* Postoperative wound infection;
* Other motor disorders, spinal cord pathologies, fractures, osteoarthritis, amputations, scoliosis and other movement-affecting diseases.

Where it's running

• The 958 Hospital of Chinese People's Liberation Army, The Jiangbei Campus of Southwest Hospital, The First Affiliated Hospital of Army Medical University
  Chongqing, Chongqing Municipality, China Recruiting
• the Southwest hospital
  Chongqing, Chongqing Municipality, China Recruiting
• Beijing TianTan Hospital
  Beijing, Beijing Municipality, China Active not recruiting
• Jingmen No.1 People's Hospital
  Jingmen, Hubei, China Active not recruiting

Study contacts

• Study coordinator: Liang Tan, Ph,D
• Email: tracy200712@hotmail.com
• Phone: 86-158-2354-0630

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.