Enhancing Smoking Cessation for Black People with HIV
Official title: A National Test of a Culturally Tailored Smartphone-based Smoking Cessation and Mental Health Intervention for Black Adults With HIV
Run by University of Houston · NCT07024992 · Data updated 2026-11-12
A smartphone-based program plus nicotine replacement is tested to help Black people living with HIV quit smoking.
Quick facts
| Phase | Phase 2 |
|---|---|
| Study type | Interventional |
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 300 (estimated) |
| Sponsor | University of Houston Academic / other |
| Locations | 1 site (Oklahoma City, Oklahoma) |
| Status | Recruiting |
| Started | June 30, 2026 |
| Main results expected | June 30, 2029 |
| Study ends | June 30, 2029 |
| Registry record updated | July 13, 2026 |
| Trial ID | NCT07024992 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are Black adults with HIV who smoke, are motivated to quit, own an Android or iPhone, and have adequate English literacy.
✕Probably not a fit
Individuals not ready to quit within 14 days, without access to a compatible smartphone, or without willingness to use NRT may not benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This phase 2 trial compares two mobile smoking cessation programs plus NRT against an assessment-only control among 300 Black adults living with HIV who smoke. Participants are randomly assigned to ESCAPE + NRT, quitSTART + NRT, or control + NRT, with remote assessments over 54 weeks and a subset completing qualitative interviews in week 6. The study uses ecological momentary assessments, regular follow-ups, and biomarker verification to measure quit rates and HIV care management outcomes. The aim is to determine whether culturally tailored mHealth support improves cessation and HIV-related health management more than standard mobile tools or no active intervention.
Why it matters
Potential benefit: If successful, participants may achieve higher quit rates and better HIV management with a culturally tailored mobile program.
How similar studies have gone: Prior mobile smoking cessation studies show benefits with app-based interventions, but this trial specifically tests a culturally tailored approach in Black people with HIV.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * At least 18 years of age * Identify as Black/African American * Living with HIV * Biochemical verification of self-reported smoking status following minimum study specified smoking rate endorsement * Motivated to quit smoking * Must be ready to quit cigarettes within 14 days of full enrollment * Moderate or higher anxiety sensitivity OR elevated anxiety OR depression * Must be willing to download a mobile app onto their personal phone * Must be willing to use NRT * Possess an Android/Apple smartphone that is compatible with the mobile app * Demonstrate 7th grade level proficiency in English (≥4 on the Rapid Estimate of Adult Literacy in Medicine-Short Form \[REALM-SF\]) * Valid proof of identification (photo of valid US ID) Exclusion Criteria: * Legal situations which may interfere with study participation * Not being fluent in English * High blood pressure that is not under control * Having experienced a heart attack within the past 2 weeks * Pregnant of planning to become pregnant within the next six months
Where it's running
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University of Oklahoma Health Sciences Center
Oklahoma City, Oklahoma, United States Recruiting
Study contacts
- Principal investigator: Michael S. Businelle, Ph.D. — University of Oklahoma Health Sciences
- Study coordinator: Lorra Garey, Ph.D.
- Email: llgarey@central.uh.edu
- Phone: 713-743-8056
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.