Enhanced recovery protocol for patients with complicated appendicitis

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This pilot study aims to evaluate the feasibility and safety of an enhanced recovery protocol for adult patients undergoing laparoscopic appendectomy for complicated appendicitis. Patients will be discharged on an oral antibiotic regimen for three days post-surgery. The study will assess feasibility through patient compliance with postoperative instructions and safety by monitoring the incidence of postoperative infectious complications and readmissions. The goal is to improve recovery outcomes and reduce hospital stays.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Individuals between the ages of 18 and 65 years of age.
* Patients undergoing a laparoscopic appendectomy.
* Diagnosis of complicated appendicitis based on pre-operative imaging or intra-operative assessment. The definition of a complicated appendicitis will include: (a) perforated appendicitis, without generalized peritonitis; (b) gangrenous appendicitis, without generalized peritonitis; (c) suppurative appendicitis; (d) iatrogenic perforation of the appendix.
* Meet criteria for discharge from the post-anesthesia care unit (PACU).
* Ability to reliably follow up with the study procedures.

Exclusion Criteria:

* Age \< 18 years or \> 65 years.
* Pregnancy.
* Homelessness.
* Patients who present with generalized peritonitis.
* Patients with comorbid conditions, including diabetes mellitus, immunosuppressed state for any reason, patients on chronic anticoagulation (excluding Aspirin 81 mg).
* Patients who present with septic shock.
* Patients who require conversion to an open appendectomy.
* Patients who present with additional findings on imaging studies or intra-operatively, including ileus or small bowel obstruction.
* Based on surgeon's clinical judgment for reasons that may not be outlined above.
* Allergy or intolerance to study medication(s)

Where it's running

• Cedars-Sinai Medical Center
  Los Angeles, California, United States Recruiting

Study contacts

• Principal investigator: Galinos Barmparas, MD — Cedars-Sinai Medical Center
• Study coordinator: Laura Sarmiento, CCRP
• Email: laura.sarmiento@cshs.org
• Phone: 310-423-4295

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Effect of extraction site and local anesthesia on pain after laparoscopic appendectomy

  This study tests whether using the periumbilical versus left lower quadrant extraction site and routine port-site local anesthesia affect postoperative pain in adults with acute appendicitis undergoing laparoscopic appendectomy.

  Recruiting Saglik Bilimleri Universitesi Gazi Yasargil Training and Research Hospital · Diyarbakır, Kayapınar · NCT07824908

• Video-based grading of intraoperative adverse events during pediatric laparoscopic appendectomy

  This project tests whether using video recordings and ClassIntra can reliably grade intraoperative adverse events in children undergoing laparoscopic appendectomy.

  Recruiting TC Erciyes University · Kayseri, Kayseri · NCT07794618

• Cuff pressure management during anesthesia for kids having laparoscopic appendectomy

  This study tests whether continuously measuring and keeping the breathing-tube cuff pressure in a safe range reduces sore throat and other airway symptoms in children after laparoscopic appendectomy.

  Recruiting Ankara Etlik City Hospital · Ankara, Yenimahalle · NCT07678086

• Diagnosing abdominal pain with a six-RNA blood test

  This study will test whether a blood test that measures six RNA markers can help doctors determine if abdominal pain in people aged 7 and older is caused by infections such as appendicitis, diverticulitis, or pyelonephritis.

  Recruiting True Bearing Diagnostics, Inc. · Washington D.C., District of Columbia · NCT07579312

• Outpatient care after emergency surgery for gangrenous appendicitis

  This trial will test whether people older than 14 with gangrenous appendicitis can be safely discharged home the same day after emergency appendectomy instead of staying in the hospital.

  Recruiting Fundación Pública Andaluza para la gestión de la Investigación en Sevilla · Seville, Sevilla · NCT07521969

• How PEG bowel preparation affects gut bacteria in people with or without an appendix

  This observational study will test whether polyethylene glycol colonoscopy prep changes gut bacteria differently in adults who have had an appendectomy compared with those who have not.

  Recruiting Tongji Hospital · Wuhan, Hubei · NCT07478029

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.