Enhanced Recovery after Surgery in Total Knee Replacement

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This randomized trial compares an Enhanced Recovery After Surgery (ERAS) protocol with conventional perioperative care in patients undergoing primary bilateral total knee arthroplasty. The study enrolled 239 adults aged 50–70 with ASA I–III status, assigning about half to ERAS and half to standard care. The ERAS approach includes preoperative physiotherapy, shorter fasting, multimodal anesthesia, and optimized perioperative management. The goal is to determine whether ERAS can reduce recovery stress and improve functional outcomes after surgery in a setting where ERAS evidence is limited. Conducted at Liaquat National Hospital in Karachi between July 2025 and January 2026, findings may inform practice in similar LMIC contexts.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* ASA grade of 1-3 BMI was restricted to less than 30 kg/m²

Exclusion Criteria:

* ASA grade of IV or higher uncontrolled comorbidities not consenting to the protocol

Where it's running

• Liaquat National Hospital
  Karachi, Sindh, Pakistan Recruiting

Study contacts

• Study coordinator: Dr Mohammad Zeeshan Haider, Mbbs
• Email: mohammadzh321@gmail.com
• Phone: +923432886821

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Heart rate variability biofeedback, mindfulness, or psychoeducation after knee replacement

  This trial tests whether heart rate variability biofeedback, mindfulness, or psychoeducation help people recover better after total knee arthroplasty.

  Recruiting at 2 sites Chang Gung Memorial Hospital · Taoyuan and 1 other locations · NCT07896954

• Enhanced Recovery After Surgery for Gynecologic Procedures

  This study tests whether an ERAS program can help women undergoing gynecologic surgery recover faster compared with traditional perioperative care.

  Recruiting National Taiwan University Hospital · Hsinchu · NCT07764276

• Pediatric ERAS-Adapted Laparoscopic Appendectomy Feasibility

  This study tests a 20-item enhanced recovery protocol in children aged 5–18 undergoing laparoscopic appendectomy to see if it can be safely and reliably applied in a real clinical setting.

  Recruiting TC Erciyes University · Kayseri, Kayseri · NCT07643285

• Binaural beats to reduce pain and anxiety after hip or knee replacement

  This will try a 30-minute binaural beats audio session in the PACU to see if it lowers pain and anxiety for adults having same-day total hip or knee replacement.

  Recruiting University of Miami · Miami, Florida · NCT07437469

• ERAS versus standard perioperative care for parent-infant bonding after cesarean delivery

  This trial will test whether using the ERAS protocol after cesarean helps mothers and fathers bond with their newborns compared with standard perioperative care.

  Recruiting Okan University · Istanbul · NCT07276126

• Prehabilitation within ERAS for gynecologic oncology surgery

  This trial tests whether a pre-surgery program of tailored exercise, immunonutrition (Ocoxin), breathing exercises and psychological support combined with ERAS helps people having gynecologic cancer surgery recover faster and with fewer complications.

  Recruiting Aristotle University Of Thessaloniki · Thessaloniki · NCT07210164

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.