Energy drink with caffeine and green tea to boost fat burning during exercise

Influence of Caffeine and Green Tea Extracts Consumption on Basal, Peri- and Post-exercise Fat Oxidation

This trial will test whether drinking an energy drink containing caffeine and green tea before exercise increases fat burning in healthy, moderately active adults.

Quick facts

• Phase: Phase 4
• Study type: Interventional
• Enrollment: 40 (estimated)
• Ages: 18 Years to 45 Years
• Sex: All
• Sponsor: RDC Clinical Pty Ltd (Industry-sponsored)
• Locations: 1 site (Southport, Queensland)
• Trial ID: NCT07434752 on ClinicalTrials.gov

What this trial studies

Healthy, moderately active adults will attend three clinic visits over 3–5 weeks in a double-blind, placebo-controlled crossover design. The first visit determines each participant's individualized cycling intensity that maximizes fat use, and at the two subsequent visits participants consume either the active drink or a placebo before a 30-minute cycling session at that intensity. Researchers will measure fat and carbohydrate oxidation, heart rate, blood pressure, and subjective responses at rest, during exercise, and after exercise. The active intervention combines caffeine and green tea extract and is compared directly with a taste-matched placebo.

Who should consider this trial

Good fit: Ideal candidates are healthy adults aged 18–45 who are moderately active (not sedentary, not doing over 150 minutes of endurance exercise per week), have a BMI of 22.0–34.9 kg/m2, and have no allergies to caffeine or green tea and no major medical conditions listed in the criteria.

Not a fit: People who are sedentary, outside the 18–45 age range, have heart disease, diabetes, gastrointestinal or coagulation disorders, are pregnant or breastfeeding, or who regularly consume caffeine/green tea products are unlikely to be eligible or benefit from the intervention.

Why it matters

Potential benefit: If successful, this could show a simple pre-exercise drink modestly increases fat burning during endurance exercise, which may help with metabolic or weight-management goals.

How similar studies have performed: Previous small studies combining caffeine and green tea extracts have shown modest increases in fat oxidation in some cases, but results across studies have been inconsistent.

Eligibility criteria

Inclusion Criteria:

* Passing the Exercise and Sport Science Australia adult pre-exercise screening system (APSS) stage 1 \& 2 (see appendix 4).
* Between the ages of 18 and 45,
* Not sedentary, and not completing more than 150 minutes of low and/or moderate and/or or vigorous intensity endurance exercise a week,
* Ability to commit to in principle fulfilment of all 3 trial visits,
* No history of coagulopathy e.g., DVT, stroke,
* No known heart disease,
* No known pancreatic insufficiency,
* No known inflammatory bowel disease, or prior bowel resection or bypass surgery (excluding gastric banding and sleeve),
* BMI of 22.0 to 34.9 kg/m2,
* No known allergies to caffeine or green tea extract,
* No known type I or II diabetes,
* No uncontrolled concurrent illness,
* No known current pregnancy or breastfeeding women
* No current regular consumption of supplements (\>2 times a week) or foods and drinks containing caffeine and/or green tea extracts (\>2 times per day, weekly).
* Agree not to consume caffeine for 12-hours prior to the clinic visit.

Exclusion Criteria:

* Triggering any of the exclusion screening criteria as outlined below, and in compliment with the Exercise and Sport Science Australia adult pre-exercise screening system (APSS).
* Under the age of 18 or over the age of 45,
* Sedentary, or completing over 150 minutes of low and/or moderate and/or or vigorous intensity endurance exercise a week,
* Inability to commit to in principle fulfilment of all 3 trial visits,
* History of coagulopathy e.g., DVT, stroke,
* Known heart disease,
* Known pancreatic insufficiency,
* Known inflammatory bowel disease, or prior bowel resection or bypass surgery (excluding gastric banding and sleeve),
* BMI \< 22.0 or \> 34.9 kg/m2,
* Known allergies to caffeine or green tea extract,
* Known type I or II diabetes,
* Uncontrolled concurrent illness,
* Taking GLP-1 agonists, caffeine, or any other medication known to affect metabolism.
* Known current pregnancy or breastfeeding women.
* Currently regularly consuming supplements, foods or drinks containing a caffeine and green tea extract blend, or not willing to abstain for the study

Where this trial is running

Southport, Queensland

• Griffith University, Gold Coast Campus — Southport, Queensland, Australia (Recruiting)

Study contacts

• Study coordinator: Llion Roberts, PhD

Conditions Exercise; metabolism