Clinical trial Recruiting at 2 sites Observational Ages 18 and up

Endovascular reopening of chronically blocked intracranial arteries

Official title: Feasibility of Endovascular Recanalization for Symptomatic Chronic Intradural Large Vessel Occlusions - Re-CHILL Study

Run by Insel Gruppe AG, University Hospital Bern · NCT07072026 · Data updated 2026-11-12

This project will try endovascular recanalization to reopen chronically blocked brain arteries in people with symptomatic intracranial large-vessel occlusions to see if it is safe and improves outcomes.

More Intracranial Artery Stenosis trials

Quick facts

Study typeObservational
Ages18 Years and up
SexAll
Enrollment80 (estimated)
SponsorInsel Gruppe AG, University Hospital Bern
Academic / other
Locations2 sites (Essen and 1 other locations)
StatusRecruiting
StartedMay 15, 2025
Main results expectedDecember 31, 2025
Study endsDecember 31, 2025
Registry record updatedJuly 18, 2025
Trial IDNCT07072026 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates are people with symptomatic chronic intracranial large-vessel occlusions from atherosclerosis (ICA, MCA, VA, or BA) who remain symptomatic despite medical therapy and are treated at a participating center.

Probably not a fit

Patients with large completed infarcts, severe comorbidities that make procedures unsafe, asymptomatic occlusions, or who decline the procedure are unlikely to benefit.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study collects consecutive patients who underwent endovascular recanalization for symptomatic chronic intradural large-vessel occlusions at participating centers between January 1, 2020 and December 31, 2024. The team will record technical success, perioperative complication rates, and clinical outcomes such as functional status and stroke recurrence. Cases include intradural internal carotid, middle cerebral, vertebral, and basilar artery occlusions and focus on procedural feasibility in these technically challenging locations. Procedural details and adverse events will be characterized to inform safety and guide future treatment strategies.

Why it matters

Potential benefit: If successful, the procedure could restore cerebral blood flow and reduce recurrent strokes and disability in selected patients.

How similar studies have gone: Small case series and single-center cohorts have reported that endovascular recanalization for chronic intracranial occlusions can be feasible, but results are mixed and intradural occlusions remain less studied and higher-risk.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* all consecutive patients who undergone endovascular recanalization for chronic intradural large vessel occlusions between January 1st, 2020, and December 31st, 2024 involving the following locations: internal carotid artery (ICA), middle cerebral artery (MCA), vertebral artery (VA), and basilar artery (BA)

Exclusion Criteria:

* presence of documented written or verbal refusal

Where it's running

  • Alfried Krupp Krankenhaus
    Essen, Germany
    Recruiting
  • Inselspital Bern, University Hospital Bern
    Bern, Switzerland
    Recruiting

Study contacts

Similar studies

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How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.