Endovascular reopening of chronically blocked intracranial arteries
Official title: Feasibility of Endovascular Recanalization for Symptomatic Chronic Intradural Large Vessel Occlusions - Re-CHILL Study
Run by Insel Gruppe AG, University Hospital Bern · NCT07072026 · Data updated 2026-11-12
This project will try endovascular recanalization to reopen chronically blocked brain arteries in people with symptomatic intracranial large-vessel occlusions to see if it is safe and improves outcomes.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 80 (estimated) |
| Sponsor | Insel Gruppe AG, University Hospital Bern Academic / other |
| Locations | 2 sites (Essen and 1 other locations) |
| Status | Recruiting |
| Started | May 15, 2025 |
| Main results expected | December 31, 2025 |
| Study ends | December 31, 2025 |
| Registry record updated | July 18, 2025 |
| Trial ID | NCT07072026 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are people with symptomatic chronic intracranial large-vessel occlusions from atherosclerosis (ICA, MCA, VA, or BA) who remain symptomatic despite medical therapy and are treated at a participating center.
✕Probably not a fit
Patients with large completed infarcts, severe comorbidities that make procedures unsafe, asymptomatic occlusions, or who decline the procedure are unlikely to benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study collects consecutive patients who underwent endovascular recanalization for symptomatic chronic intradural large-vessel occlusions at participating centers between January 1, 2020 and December 31, 2024. The team will record technical success, perioperative complication rates, and clinical outcomes such as functional status and stroke recurrence. Cases include intradural internal carotid, middle cerebral, vertebral, and basilar artery occlusions and focus on procedural feasibility in these technically challenging locations. Procedural details and adverse events will be characterized to inform safety and guide future treatment strategies.
Why it matters
Potential benefit: If successful, the procedure could restore cerebral blood flow and reduce recurrent strokes and disability in selected patients.
How similar studies have gone: Small case series and single-center cohorts have reported that endovascular recanalization for chronic intracranial occlusions can be feasible, but results are mixed and intradural occlusions remain less studied and higher-risk.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * all consecutive patients who undergone endovascular recanalization for chronic intradural large vessel occlusions between January 1st, 2020, and December 31st, 2024 involving the following locations: internal carotid artery (ICA), middle cerebral artery (MCA), vertebral artery (VA), and basilar artery (BA) Exclusion Criteria: * presence of documented written or verbal refusal
Where it's running
-
Alfried Krupp Krankenhaus
Essen, Germany Recruiting -
Inselspital Bern, University Hospital Bern
Bern, Switzerland Recruiting
Study contacts
- Study coordinator: Petra Cimflova, MD, PhD
- Email: petra.cimflova@insel.ch
- Phone: +41316640831
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.