Endoscopic vs. open surgery for gynecomastia
Official title: Prospective Comparative Evaluation of Different Surgical Techniques in the Treatment of Gynecomastia: A Multicenter Study
Run by Antalya City Hospital · NCT07653152 · Data updated 2026-11-12
This study compares endoscopic and traditional open surgery to treat gynecomastia in adult men to see which gives better cosmetic results, safety, and satisfaction.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years to 60 Years |
| Sex | Men only |
| Enrollment | 100 (estimated) |
| Sponsor | Antalya City Hospital Academic / other |
| Locations | 2 sites (Antalya and 1 other locations) |
| Status | Recruiting |
| Started | January 8, 2026 |
| Main results expected | January 8, 2027 |
| Study ends | January 8, 2028 |
| Registry record updated | June 17, 2026 |
| Trial ID | NCT07653152 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are men 18–60 with Simon Grade II or III gynecomastia undergoing nipple-areola complex-preserving surgery who can consent and commit to 12 months of follow-up.
✕Probably not a fit
Patients with lipomastia-only gynecomastia, prior chest surgery, or uncontrolled comorbidities may not experience benefit from endoscopic techniques.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study enrolls men aged 18–60 with confirmed gynecomastia who are undergoing nipple-areola complex-preserving mastectomy by either endoscopic or conventional open techniques. Researchers will compare outcomes such as cosmetic appearance, patient satisfaction, complication rates, sensory changes, and quality of life over a 12-month follow-up. The goal is to see if the less invasive endoscopic approach offers advantages over the standard open method in routine clinical care. Data will come from real-world surgical practices at Antalya City Hospital and collaborating center locations. No randomized assignment is described; treatment choice is based on clinical practice and patient preference.
Why it matters
Potential benefit: If successful, patients may experience better cosmetic results, fewer complications, and higher satisfaction with endoscopic surgery.
How similar studies have gone: Previous observations in surgical approaches suggest potential cosmetic and safety advantages for minimally invasive techniques, but direct endoscopic versus open comparisons for gynecomastia are limited.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Male patients aged 18 to 60 years. * Clinically and/or ultrasonographically confirmed primary gynecomastia with palpable glandular tissue ≥2 cm. * Simon Grade II or Grade III gynecomastia. * Patients requesting surgical treatment because of cosmetic and/or psychosocial concerns. * Eligible for either endoscopic or conventional open nipple-areola complex-preserving mastectomy according to routine clinical practice. * Ability to provide written informed consent. * Willingness and ability to comply with the 12-month follow-up schedule. Exclusion Criteria: * Secondary gynecomastia caused by endocrine disorders, medications, hypogonadism, thyroid disease, or suspected malignancy. * Pseudogynecomastia (lipomastia without glandular proliferation). * Age younger than 18 years or older than 60 years. * Severe uncontrolled comorbidities that may increase surgical risk. * Previous chest or breast surgery, chest irradiation, or significant chest trauma. * Active infection or coagulation disorder. * Immunodeficiency disorders. * Inability to provide informed consent. * Inability to complete the planned follow-up period.
Where it's running
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Antalya City Hospital
Antalya, Turkey (Türkiye) Recruiting -
Bagcilar Training and Research Hospital
Istanbul, Turkey (Türkiye) Recruiting
Study contacts
- Study coordinator: Mehmet Olcum
- Email: mehmetolcum@hotmail.com
- Phone: +905388101828
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.