Endoscopic removal of pituitary adenomas using pseudocapsule technique

Department of Neurosurgery, Affiliated Hospital of Nantong University

This study is testing a new way to surgically remove pituitary tumors using a special technique that aims to take out more of the tumor while keeping healthy pituitary tissue safe.

Quick facts

• Phase: NA
• Study type: Interventional
• Enrollment: 30 (estimated)
• Ages: 18 Years to 75 Years
• Sex: All
• Sponsor: Affiliated Hospital of Nantong University (other)
• Drugs / interventions: radiation
• Locations: 1 site (Nantong, Jiangsu)
• Trial ID: NCT05466357 on ClinicalTrials.gov

What this trial studies

This clinical trial focuses on the surgical resection of pituitary adenomas using an endoscopic endonasal approach that emphasizes the pseudocapsule surrounding the tumor. The study aims to evaluate the effectiveness of extracapsular resection, which utilizes high-resolution MRI to identify the pseudocapsule as a surgical plane for more radical tumor removal while preserving normal pituitary function. By refining surgical techniques and imaging protocols, the trial seeks to improve patient outcomes and reduce postoperative complications associated with pituitary adenoma surgeries.

Who should consider this trial

Good fit: Ideal candidates for this study are patients diagnosed with pituitary adenomas who are eligible for surgical intervention.

Not a fit: Patients with other primary endocrine diseases, significant tumor extensions, or serious comorbidities may not benefit from this study.

Why it matters

Potential benefit: If successful, this approach could lead to more effective and safer surgical outcomes for patients with pituitary adenomas.

How similar studies have performed: Previous studies have shown promise in using the endoscopic endonasal approach for pituitary adenomas, but the specific focus on the pseudocapsule technique is relatively novel.

Eligibility criteria

Inclusion criteria:

According to guidelines for treatment of pituitary tumors，Patients can be eligible for surgery.

Exclusion criteria:

1. Patients with other primary endocrine diseases.
2. Patients with obviously suprasellar and parasellar extensions or with cavernous sinus invasion (grade 4 of knosp classification ).
3. Patients with recent nasal trauma.
4. Patients with nasal infection or/and sphenoid sinus inflammation.
5. Patients with with abnormal coagulation.
6. Patients with other serious diseases.

Where this trial is running

Nantong, Jiangsu

• Affiliated Hospital of Nantong University — Nantong, Jiangsu, China (RECRUITING)

Study contacts

• Principal investigator: xiao mingbing, MD — Affiliadted hospital of nantong university
• Study coordinator: shi wei, MD

Conditions: Pituitary Adenoma, pituitary adenomas, pseudocapsule, the endoscopic endonasal approach