Endoscopic and shockwave therapy for painless chronic pancreatitis

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This interventional study enrolls adults aged 18–85 with painless chronic pancreatitis and no prior ERCP or ESWL to receive standard medical care plus endoscopic retrograde cholangiopancreatography (ERCP) and/or extracorporeal shockwave lithotripsy (ESWL) as indicated. Participants may also receive lifestyle advice, pancreatic enzyme replacement, and antidiabetic medications according to clinical need. Key exclusions include complications requiring surgical intervention, autoimmune pancreatitis, suspected malignancy, prior pancreatic or gastrointestinal bypass surgery, end-stage disease, pregnancy, and contraindications to ERCP/ESWL. The study is conducted at Changhai Hospital in Shanghai and compares clinical outcomes following these interventions in the painless CP population.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Adults aged 18-85 years.
* Diagnosed with painless chronic pancreatitis.
* No prior history of endoscopic retrograde cholangiopancreatography (ERCP) or extracorporeal shockwave lithotripsy (ESWL) treatment.
* Stone(s) in the cephalic or corporeal portion of the main pancreatic duct with upstream duct dilation

Exclusion Criteria:

* Presence of complications requiring endoscopic or surgical intervention, such as pancreatic pseudocysts, benign biliary strictures, pancreatic fistulas, or pancreatic portal hypertension.
* Autoimmune pancreatitis.
* Suspected malignancy.
* History of pancreatic surgery or gastrointestinal bypass surgery (e.g., Billroth II procedure).
* End-stage disease.
* Pregnancy or lactation.
* Contraindications to ESWL or ERCP.
* Refusal to provide informed consent.

Where it's running

• Changhai Hospital
  Shanghai, Shanghai Municipality, China Recruiting

Study contacts

• Study coordinator: Zhao-Shen Li
• Email: zhaoshen-li@hotmail.com
• Phone: +8613901960921

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.