Empiric prehospital transfusion bundle for traumatic haemorrhagic shock

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a prospective observational implementation of a prehospital transfusion bundle delivered by the Medical University of Graz emergency doctor response team and the Graz HEMS. Only adults with suspected life‑threatening traumatic bleeding who receive prehospital transfusion and are transported to the resuscitation room at the Medical University of Graz will be included. The bundled intervention follows local SOPs and consists of two units of fibrinogen and plasma plus tranexamic acid at 10–20 mg/kg. The project aims to collect real‑world data on benefits and harms after introducing this change to prehospital routine care.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* aged, or believed to be aged
* 18 years or above
* confirmed or suspected life-threatening bleeding from trauma (i.e. signs of inadequate perfusion of tissues, tachycardia, hypotension, suspected blood loss)
* need for volume replacement therapy.

Exclusion Criteria:

* patient with known recent history of thromboembolic events within the last 6 months
* known or suspected pregnancy at presentation
* patient with known refusal of a participation in this clinical trial.

Where it's running

• Medical University of Graz
  Graz, Austria Recruiting

Study contacts

• Principal investigator: Gabriel Honnef, MD, PhD — Medical University of Graz, Department of Anaesthesiology
• Study coordinator: Gabriel Honnef, MD, PhD
• Email: gabriel.honnef@medunigraz.at
• Phone: +436509160890

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Simplified Tranexamic Acid Regimen for Trauma with Hemorrhage

  This trial tests a simplified TXA dosing approach to see if it safely helps adults with major trauma and significant bleeding.

  Recruiting at 3 sites Phase 4 Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou, Zhejiang and 2 other locations · NCT07869537

• Stability of blood clotting products in ambulances under real-world conditions

  This study checks whether fibrinogen concentrates and Octaplas plasma stay stable when stored in real EMS ambulances in Graz, Austria.

  Recruiting Medical University of Graz · Graz · NCT07646964

• Rapid bedside fibrinogen testing for bleeding trauma patients in the emergency department

  This will test a rapid bedside fibrinogen test for adults with traumatic bleeding to help decide who needs fibrinogen replacement.

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• Using ROTEM analysis to improve outcomes in sepsis and trauma patients

  This study is testing if a special blood test can help doctors spot early signs of serious blood clotting issues in patients with sepsis or trauma to improve their treatment.

  Recruiting Region Stockholm · Stockholm · NCT06891599

• Using tranexamic acid to treat traumatic bleeding with real-time monitoring

  This study tests whether giving tranexamic acid in a new way, based on real-time blood monitoring, can help patients with severe trauma stop bleeding better and reduce the risk of complications.

  Recruiting Phase 4 Nanfang Hospital, Southern Medical University · Guangzhou, Guangdong · NCT06736860

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.