Clinical trial Recruiting at 1 site Observational Ages 18 to 65

Emotion regulation in people who experience repetitive negative thinking

Official title: The Neural Mechanisms of Emotion Dysregulation in Repetitive Negative Thinking (RNT) Patients: A Pilot Study

Run by University Hospital, Ghent · NCT07513766 · Data updated 2026-11-12

This project will use harmless infrared brain imaging to see if people who habitually ruminate show different brain responses during emotion-regulation tasks compared with matched healthy adults.

Quick facts

Study typeObservational
Ages18 Years to 65 Years
SexAll
Enrollment100 (estimated)
SponsorUniversity Hospital, Ghent
Academic / other
Locations1 site (Ghent)
StatusRecruiting
StartedJune 5, 2024
Main results expectedMarch 30, 2026
Study endsDecember 30, 2026
Registry record updatedApril 7, 2026
Trial IDNCT07513766 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Adults diagnosed with major depressive disorder or generalized anxiety disorder who report high repetitive negative thinking, and matched healthy adults with no history of psychopathology, are ideal candidates.

Probably not a fit

People seeking immediate therapeutic changes, those without the target diagnoses, or individuals unable to attend in-person visits are unlikely to gain direct benefit because this is an observational imaging study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study will compare adults with high levels of repetitive negative thinking (linked to depression or generalized anxiety disorder) to age- and sex-matched healthy controls. Participants will complete emotion-regulation tasks on a computer while researchers record brain activity using functional near-infrared spectroscopy (fNIRS). The team will analyze how communication between brain networks differs during emotional challenges and regulatory attempts. All visits take place at University Hospital Ghent and no experimental treatment is given.

Why it matters

Potential benefit: If successful, the findings could identify brain-activity patterns that help guide treatments to reduce rumination and improve emotion regulation in depression and anxiety.

How similar studies have gone: Previous neuroimaging work (including fMRI and some fNIRS studies) has reported altered emotion-regulation and network connectivity in rumination, though applying fNIRS to this specific clinical comparison remains partly novel.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Patient group: diagnosis of depression/GAD
* Healthy control group: no history of or current form of psychopathology

Where it's running

  • University Hospital Ghent, Ghent, East-Flanders 9000
    Ghent, Belgium
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.