Emotion regulation in people who experience repetitive negative thinking
Official title: The Neural Mechanisms of Emotion Dysregulation in Repetitive Negative Thinking (RNT) Patients: A Pilot Study
Run by University Hospital, Ghent · NCT07513766 · Data updated 2026-11-12
This project will use harmless infrared brain imaging to see if people who habitually ruminate show different brain responses during emotion-regulation tasks compared with matched healthy adults.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years to 65 Years |
| Sex | All |
| Enrollment | 100 (estimated) |
| Sponsor | University Hospital, Ghent Academic / other |
| Locations | 1 site (Ghent) |
| Status | Recruiting |
| Started | June 5, 2024 |
| Main results expected | March 30, 2026 |
| Study ends | December 30, 2026 |
| Registry record updated | April 7, 2026 |
| Trial ID | NCT07513766 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults diagnosed with major depressive disorder or generalized anxiety disorder who report high repetitive negative thinking, and matched healthy adults with no history of psychopathology, are ideal candidates.
✕Probably not a fit
People seeking immediate therapeutic changes, those without the target diagnoses, or individuals unable to attend in-person visits are unlikely to gain direct benefit because this is an observational imaging study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study will compare adults with high levels of repetitive negative thinking (linked to depression or generalized anxiety disorder) to age- and sex-matched healthy controls. Participants will complete emotion-regulation tasks on a computer while researchers record brain activity using functional near-infrared spectroscopy (fNIRS). The team will analyze how communication between brain networks differs during emotional challenges and regulatory attempts. All visits take place at University Hospital Ghent and no experimental treatment is given.
Why it matters
Potential benefit: If successful, the findings could identify brain-activity patterns that help guide treatments to reduce rumination and improve emotion regulation in depression and anxiety.
How similar studies have gone: Previous neuroimaging work (including fMRI and some fNIRS studies) has reported altered emotion-regulation and network connectivity in rumination, though applying fNIRS to this specific clinical comparison remains partly novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patient group: diagnosis of depression/GAD * Healthy control group: no history of or current form of psychopathology
Where it's running
-
University Hospital Ghent, Ghent, East-Flanders 9000
Ghent, Belgium Recruiting
Study contacts
- Principal investigator: Chris Baeken — University Ghent
- Study coordinator: Chris Baeken
- Email: Chris.Baeken@ugent.be
- Phone: +32476209841
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Imaging Mitochondrial Complex-I and Brain Metabolism in Alcohol Use Disorder
This study tests whether PET imaging with [18F]BCPP-EF and [18F]FDG can reveal differences in brain energy use between adults with alcohol use disorder and healthy controls, and whether these measures relate to relapse risk.
-
Vagustim taVNS: Testing a sham in adults for immune-related conditions
This small, double-blind study tests whether Vagustim taVNS’s sham method works as a believable placebo in healthy adults.
-
Imaging Brain Mitochondrial Complex-I in Cocaine Use Disorder
This study uses a PET scan with [F-18]BCPP-EF to see how mitochondrial Complex-I activity in the brain differs between people with cocaine use disorder and healthy controls.
-
Walking adaptability and foot tapping measurements in people with multiple sclerosis
This test compares the Walking Adaptability Ladder Test and Foot Tap Test in people with mild multiple sclerosis and matched healthy adults to see if they reliably detect subtle walking and motor changes.
-
Colored-light pain relief and brain mapping in chronic musculoskeletal pain
This trial will test whether showing different colored lights to the eyes can reduce pain and change brain activity in adults with chronic musculoskeletal pain compared with healthy, age- and sex-matched controls.
-
Mindfulness-based neurofeedback for teens with high repetitive negative thinking
This study will see if real-time fMRI mindfulness-based neurofeedback helps adolescents with high repetitive negative thinking reduce brain network activity linked to rumination compared with a sham procedure and healthy peers.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.