Embolization of the Inferior Mesenteric Artery before Rectal Surgery

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the safety and efficacy of embolizing the inferior mesenteric artery prior to surgery for tumors of the lower and middle rectum. The approach aims to induce ischemic preconditioning, which may enhance vascularization and reduce complications such as postoperative fistulas. By performing this embolization three weeks before surgery, the study seeks to improve colonic blood flow and overall surgical outcomes. The research will also evaluate the impact of this procedure on colonic vasculature and postoperative recovery.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients with rectal cancer eligible for surgery with ligation at the origin of the inferior mesenteric artery.
* Patients with free, informed consent.
* Patients affiliated to or benefiting from a health insurance plan.

Exclusion Criteria:

* Patients with a history of colon cancer who has undergone colon resection surgery
* Patients with occlusion of the superior mesenteric artery or stenosis of more than 50%, visible on the CT scan performed as part of conventional management during extension workup.
* Patients with occlusion of the IMA on the extension scan.
* Patients with a systemic disorder responsible for haemostasis (haemophilia, Willebrand's disease, thrombocytopenia) and on anticoagulant therapy.
* Patients taking corticosteroids or immunosuppressants leading to an unacceptable surgical risk.
* Patients with renal insufficiency with clearance \< 30mL/min.
* Patients with an allergy to iodine.
* Patients who has had treatment of the abdominal aorta or its branches.
* Patients participating in an interventional study.
* Patients in an exclusion period determined by another study.
* Patients under court protection, guardianship or curatorship.
* Patients unable to give consent.
* Patients for whom it is impossible to provide informed information.
* Pregnant or breast-feeding patients.

Where it's running

• Hôpital Saint-Eloi
  Montpellier, France Recruiting
• Institut du Cancer de Montpellier
  Montpellier, France Recruiting
• CHU de Nîmes
  Nîmes, France Recruiting

Study contacts

• Study coordinator: Martin BERTRAND, Professor
• Email: martin.bertrand@chu-nimes.fr
• Phone: +336.43.50.35.22

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.