Embolization of the inferior mesenteric artery before colorectal surgery
Preoperative Embolization of the Inferior Mesenteric Artery in Colorectal Surgery
NA · University Hospital, Grenoble · NCT05422560
This study is testing if blocking a specific artery before colorectal surgery can help patients heal better and reduce the chances of complications.
Quick facts
| Phase | NA |
|---|---|
| Study type | Interventional |
| Enrollment | 30 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | University Hospital, Grenoble (other) |
| Locations | 3 sites (Clermont-Ferrand and 2 other locations) |
| Trial ID | NCT05422560 on ClinicalTrials.gov |
What this trial studies
This study investigates the effects of preoperative embolization of the inferior mesenteric artery in patients undergoing colorectal surgery. By performing embolization a few weeks prior to surgery, the goal is to enhance the vascularization of the anastomosis site, potentially reducing the risk of anastomotic leaks, a common complication in colorectal procedures. The study is monocentric and non-randomized, focusing on adult patients who require left colonic or rectal surgery. The approach is based on previous successes in esophageal surgery, aiming to improve patient outcomes in colorectal surgery.
Who should consider this trial
Good fit: Ideal candidates include adult patients scheduled for left colonic or rectal surgery involving ligation of the inferior mesenteric artery.
Not a fit: Patients with a history of digestive resection or severe renal failure, as well as pregnant or lactating women, may not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could significantly reduce the incidence of anastomotic leaks in colorectal surgery patients.
How similar studies have performed: Previous studies in esophageal surgery have shown success with similar embolization techniques, suggesting potential for positive outcomes in colorectal surgery as well.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Adult patients * Patient to benefit from left colonic surgery or rectal surgery with upper ligation of the inferior mesenteric artery and colorectal or colo anastomosis * Person affiliated to or benefiting from social security * Person who has given written informed consent Exclusion Criteria: * History of digestive resection or abdominal aorta surgery * Renal failure with GFR \< 30 ml/min (MDRD) * History of severe allergy to iodine contrast medium * Pregnant, parturient, lactating women * Patient subject to a legal protection measure or unable to express his non-opposition (guardianship, curatorship) * Patient deprived of liberty by judicial or administrative decision
Where this trial is running
Clermont-Ferrand and 2 other locations
- Centre Hospitalier Universitaire de Clermont-Ferrand — Clermont-Ferrand, France (NOT_YET_RECRUITING)
- Groupe Hospitalier Mutualiste — Grenoble, France (RECRUITING)
- Grenoble Alpes University Hospital — Grenoble, France (RECRUITING)
Study contacts
- Principal investigator: Julien GHELFI, MD — Grenoble Alpes University Hospital
- Study coordinator: Marine FAURE
- Email: MFaure6@chu-grenoble.fr
- Phone: 0476766872
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Embolism Mesenteric, Colorectal surgery, Ischemic conditioning, Embolization, Inferior mesenteric artery, Anastomotic fistula