Eltroxin treatment for ICU patients with very low T4 levels
Eltroxin Administration to Patients With Extremely Low T4 Values in the Intensive Care Unit: Comparison Between Groups and Therapeutic Outcomes
This study is testing if giving Eltroxin to ICU patients with very low thyroid hormone levels can improve their health outcomes.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 350 (estimated) |
| Ages | 18 Years to 99 Years |
| Sex | All |
| Sponsor | Meir Medical Center Academic / other |
| Locations | 1 site (Kfar Saba) |
| Trial ID | NCT06154382 on ClinicalTrials.gov |
What this trial studies
This observational study investigates the administration of Eltroxin to patients in the intensive care unit who exhibit extremely low T4 hormone levels, a condition often associated with critical illnesses. The study aims to understand the relationship between low thyroid hormone levels and patient outcomes, particularly in those suffering from severe conditions like sepsis and acute respiratory failure. By focusing on patients with T4 levels below 50% of the normal range, the research seeks to evaluate the potential therapeutic benefits of Eltroxin in this vulnerable population.
Who should consider this trial
Good fit: Ideal candidates include adults aged 18-99 admitted to the ICU with significantly low T4 levels.
Not a fit: Patients with pre-existing chronic thyroid dysfunction or those previously treated with Eltroxin will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could improve treatment outcomes for critically ill patients with low T4 levels.
How similar studies have performed: Previous studies have indicated a correlation between nonthyroidal illness and poor outcomes, suggesting that this approach may yield valuable insights.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: All patients aged 18--99 who were admitted to the general intensive care unit from January 2016 to November 22, 2023 for any reason, and who during their hospitalization in the intensive care unit had lower than normal T4 levels measured. It is about 350 patients. Of these, we will specifically examine the group of patients for whom an extremely low level of T4 was measured (less than 50% of the lower limit of the norm). \- Exclusion Criteria: Patients who were known to have a chronic thyroid dysfunction prior to their hospitalization in the unit, patients who were regularly treated with eltroxin prior to their hospitalization \-
Where this trial is running
Kfar Saba
- Meir Medical Center — Kfar Saba, Israel (Recruiting)
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.