Elevating maxillary sinuses for dental implants

Transalveolar Crest Parietal Sinus Floor Lift and Secondary Lift for Postoperative Improvement of Neonatal Bone Mass in Sinus: a Prospective Clinical Study in the Posterior Maxillary Region

This study is testing a procedure to lift the maxillary sinuses to see if it helps people get dental implants in the back of their mouths.

Quick facts

• Phase: Not applicable
• Study type: Interventional
• Enrollment: 40 (estimated)
• Ages: 18 Years and up
• Sex: All
• Sponsor: Nanfang Hospital, Southern Medical University (Academic / other)
• Drugs / interventions: chemotherapy
• Locations: 1 site (Guangzhou, Guangdong)
• Trial ID: NCT06106321 on ClinicalTrials.gov

What this trial studies

This clinical trial involves approximately 40 participants who will undergo a maxillary sinus floor lift procedure to facilitate dental implant placement in the posterior maxillary region. Participants will be screened for eligibility and will receive either the experimental or control treatment based on the study protocol. The study aims to evaluate subjective perceptions and changes in soft and hard tissues at 3 months, 6 months, and 1 year post-implant placement. All subjects will provide informed consent and undergo necessary preoperative examinations.

Who should consider this trial

Good fit: Ideal candidates are adults aged 18 and older who have been missing posterior maxillary teeth for at least 3 months and meet specific radiological criteria for sinus lift procedures.

Not a fit: Patients with uncontrolled diabetes, heavy smokers, or those with a history of sinus disease or previous sinus surgery may not benefit from this study.

Why it matters

Potential benefit: If successful, this study could improve the success rates of dental implants in patients with tooth loss in the posterior maxillary region.

How similar studies have performed: Other studies have shown success with similar maxillary sinus lift procedures, indicating a potential for positive outcomes in this area.

Eligibility criteria

Inclusion Criteria:

1. Age≥ 18 years old
2. If the posterior maxillary tooth is missing for ≥ 3 months, the patient requires implant restoration and the preoperative examination meets the indications for intramaxillary sinus lift
3. Can be scanned with radiology equipment before and after surgery
4. RBH ≤ 5mm, alveolar ridge width ≥5mm, each implant site is measured on CBCT
5. During implant healing, there is no removable restoration at the implant site
6. No history of acute or chronic sinusitis disease, no history of maxillary sinus disease, and no history of previous maxillary sinus surgery
7. Be willing to sign informed consent and authorization form, and be able to return to the clinic on time

Exclusion Criteria:

1. Heavy smokers (10 cigarettes smoked ≥ day)
2. Uncontrolled diabetes (glycated hemoglobin \>7%), metabolic bone disease, autoimmune disease or other systemic diseases, the body can hardly withstand implant surgery
3. Mentally unable, pregnant or pregnant women
4. Any history of contraindications or significant impact on dental implant placement, such as bisphosphonate drug use, chemotherapy or immunosuppressants, head and neck radiotherapy, autoimmune disease, and hypertension
5. Untreated periodontal disease, endodontics, or other oral diseases
6. Bruxism patients
7. Previous implant implant failure at the surgical site
8. Anatomical changes in the maxillary sinus, such as maxillary sinus septum or mucosal swelling (defined as the mean thickness of the Schneider membrane at the base of the maxillary sinus \> 2 mm)

Where this trial is running

Guangzhou, Guangdong

• NanFang Hospital of Sourthern Medical University — Guangzhou, Guangdong, China (Recruiting)

Study contacts

• Study coordinator: Qi Liu, Ph.D

Conditions Tooth Loss