EHR-linked tools and tailored videos to help parents and clinicians discuss vaccines

Improving Vaccine Acceptance Through EHR Integrated Patient- and Provider-Facing Decision Support

Not applicable Interventional Johns Hopkins Bloomberg School of Public Health · NCT06482450

This project will try EHR-integrated tailored vaccine videos, provider talking points, and appointment reminders for parents and clinicians at a pediatric clinic to see if they increase vaccine uptake.

Quick facts

PhaseNot applicable
Study typeInterventional
Enrollment1200 (estimated)
SexAll
SponsorJohns Hopkins Bloomberg School of Public Health Academic / other
Locations1 site (Atlanta, Georgia)
Trial IDNCT06482450 on ClinicalTrials.gov

What this trial studies

Johns Hopkins, Emory, and Children's Healthcare of Atlanta are building an integrated platform that delivers LetsTalkShots (LTS) tailored vaccine videos to patients/parents and pushes the same tailored talking points into the electronic health record for clinicians. The platform is designed to surface patient-specific talking points in clinical workflows at the right time, centralize messaging maintenance through LTS, and minimize site-specific implementation work. Providers at the CHOA Hughes Spalding Primary Care clinic will receive brief CME opportunities and clinicians and families will receive appointment reminders, with an initial phase focused on COVID-19 vaccines followed by all routine vaccines. The project will measure whether the integrated approach increases vaccine uptake among patients due for vaccines.

Who should consider this trial

Good fit: Children with an upcoming appointment at the CHOA Hughes Spalding Primary Care Clinic who are due for recommended vaccines and have a valid mobile phone number or e-mail in the EHR two business days before the visit are ideal candidates.

Not a fit: Patients who are not due for any vaccines, who do not have a valid phone or email in the EHR, or who do not attend the participating clinic are unlikely to benefit from this intervention.

Why it matters

Potential benefit: If successful, the platform could increase vaccine uptake and make vaccine conversations more personalized and easier for parents and clinicians.

How similar studies have performed: Prior work on tailored messaging and clinician prompts has shown promise for improving vaccine attitudes and uptake, but large-scale EHR-integrated implementations like this are less well tested.

Eligibility criteria

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Patient has an upcoming appointment in 2 business days at Children's Healthcare of Atlanta Hughes Spalding Primary Care Clinic.
* A valid mobile phone number or e-mail address is available in the EHR as of 2 business days prior to the appointment date.

Phase 1: COVID-19 Vaccine only:

* Due for a COVID-19 vaccine based on Epic Systems© COVID-19 vaccine health maintenance topic.

Phase 2: All Vaccines:

* Due for any vaccines based on Epic Systems© implementation using health maintenance topics of the Centers for Disease Control CDS for Immunization (CDSi) specifications.

Exclusion Criteria:

* None

Where this trial is running

Atlanta, Georgia

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions Vaccine HesitancyVaccine Refusal
Last reviewed 2026-06-10 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.