Effects of whole-body cryostimulation on patients with obesity, fibromyalgia, and neurological conditions
Official title: A Non-randomized Pilot Study of the Impact on Rehabilitation Outcomes of a Course of Whole-body Cryostimulation (WBC) Treatment on Patients With Metabolic or Neurological Diseases or Fibromyalgia
Run by Istituto Auxologico Italiano · NCT05443100 · Data updated 2026-11-12
This study is testing if whole-body cryostimulation can help people with obesity, fibromyalgia, and neurological conditions feel better by reducing pain and inflammation.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 65 Years |
| Sex | All |
| Enrollment | 300 (estimated) |
| Sponsor | Istituto Auxologico Italiano Academic / other |
| Locations | 1 site (Oggebbio, Verbano-Cusio-Ossola) |
| Status | Recruiting |
| Started | April 1, 2019 |
| Main results expected | December 30, 2025 |
| Study ends | December 30, 2026 |
| Registry record updated | August 4, 2025 |
| Trial ID | NCT05443100 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are adults aged 18-65 with a BMI greater than 35 who are experiencing obesity-related complications or have fibromyalgia or neurological conditions.
✕Probably not a fit
Patients with severe psychiatric conditions, acute respiratory or cardiovascular diseases, or those who have recently lost weight may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This clinical trial investigates the impact of 10 sessions of whole-body cryostimulation (WBC) on patients with obesity, fibromyalgia, and various neurological conditions. The study aims to assess whether WBC can enhance thermogenesis, reduce inflammation, alleviate pain, and improve functional and psychological capacities in these patient populations. Participants will include individuals with a BMI greater than 30, as well as those diagnosed with fibromyalgia and neurological disorders such as Parkinson's disease and Multiple Sclerosis. The trial is conducted by Istituto Auxologico Italiano, which focuses on innovative therapeutic modalities for rehabilitation.
Why it matters
Potential benefit: If successful, this study could provide a novel treatment option that improves physical and psychological well-being for patients suffering from obesity, fibromyalgia, and neurological disorders.
How similar studies have gone: While the approach of using whole-body cryostimulation is innovative, previous studies have indicated potential benefits in reducing inflammation and improving symptoms in similar patient populations.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * both sexes * age 18-65 yrs * BMI \> 35 kg/m2 Exclusion Criteria: * severe psychiatric conditions * acute respiratory disease * acute cardiovascular disease * unstable hypertension * cold intolerance * claustrophobia * pregnancy * recent modification of usual drug treatment * previous treatment with WBC * weight loss in the last 3 months * body temperature greater than 37.5°C.
Where it's running
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IRCCS Istituto Auxologico Italiano Ospedale San Giuseppe
Oggebbio, Verbano-Cusio-Ossola, Italy Recruiting
Study contacts
- Principal investigator: Paolo Capodaglio, Prof, MD — IRCCS Istituto Auxologico Italiano
- Study coordinator: Paolo Capodaglio, Prof, MD
- Email: p.capodaglio@auxologico.it
- Phone: +39 0323514331
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.