Effects of Vitamin K2 on Bone Healing After Tooth Extraction

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial investigates the impact of socket grafting with crushed vitamin K2 (menaquinone) capsules compared to no grafting on bone density and socket dimensions following tooth extraction. Patients scheduled for tooth extraction are randomly assigned to either receive the vitamin K2 graft or undergo socket healing without grafting. The study evaluates bone socket dimensions immediately after extraction and again after four months using cone beam computed tomography (CBCT) radiographs, along with core biopsies taken at the time of implant placement. The goal is to determine if vitamin K2 can enhance bone remodeling in socket preservation.

Why it matters

Who can join: the full rules

Inclusion Criteria:• Age \> 18 years without other age or gender restrictions.

* Patients requiring extraction of mandibular single-rooted teeth.

Exclusion Criteria:

* • Patients with systemic conditions affecting bone metabolism.

  * Allergies or sensitivities to hydroxyapatite or Vitamin K2
  * Untreated or residual periodontal disease;
  * Uncontrolled diabetes (HbA1c \> 7.5%);
  * Head and/or neck radiotherapy
  * Immunosuppressive therapy
  * Pregnant or nursing
  * Substance abuse
  * Treated or under treatment with intravenous amino-bisphosphonates
  * Patients participating in other studies, if the present protocol could not be properly followed.

Where it's running

• Cairo
  Cairo, Cairo Governorate, Egypt Recruiting

Study contacts

• Study coordinator: mohamed elsawaf, BDS
• Email: mohamed.elsawaf@dentistry.cu.edu.eg
• Phone: 01124145951

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Thymoquinone 0.2% Gel to Protect Bone After Tooth Extraction

  A gel with 0.2% thymoquinone is tested to see if it helps keep bone density and width after pulling a back upper tooth in adults.

  Recruiting Kafrelsheikh University · Kafr ash Shaykh, Kafrelsheikh · NCT07765745

• Comparing two bone grafts to preserve the socket after tooth extraction

  This test will compare an allograft and a bovine xenograft to see which better preserves jaw bone and gum shape after tooth extraction in healthy adults aged 21–50.

  Recruiting Pharos University in Alexandria · Alexandria · NCT07344025

• Preserving the jawbone after a tooth extraction using hyaluronic acid and polynucleotides

  This trial will test whether filling an extraction socket with a bovine bone graft plus a polynucleotide-rich hyaluronic acid gel helps preserve the jawbone and supports implant placement in adults needing a single tooth extraction.

  Recruiting at 2 sites University of Parma · Parma and 1 other locations · NCT07099846

• Evaluating the effects of vitamin C on bone preservation after tooth extraction

  This study is testing if adding vitamin C to a bone graft after tooth extraction can help preserve bone better than just using the graft alone.

  Recruiting Cairo University · Cairo · NCT06569264

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.