Effects of Vitamin K2 on Bone Healing After Tooth Extraction
The Local Effect of Vitamin K2 on Bone Remodeling in Socket Preservation of Mandibular Single Rooted Teeth Randomized Clinical Trail
PHASE4 · Cairo University · NCT06707909
This study is testing whether using vitamin K2 during tooth extraction can help improve bone healing compared to not using it.
Quick facts
| Phase | PHASE4 |
|---|---|
| Study type | Interventional |
| Enrollment | 20 (estimated) |
| Ages | 18 Years to 80 Years |
| Sex | All |
| Sponsor | Cairo University (other) |
| Locations | 1 site (Cairo, Cairo Governorate) |
| Trial ID | NCT06707909 on ClinicalTrials.gov |
What this trial studies
This clinical trial investigates the impact of socket grafting with crushed vitamin K2 (menaquinone) capsules compared to no grafting on bone density and socket dimensions following tooth extraction. Patients scheduled for tooth extraction are randomly assigned to either receive the vitamin K2 graft or undergo socket healing without grafting. The study evaluates bone socket dimensions immediately after extraction and again after four months using cone beam computed tomography (CBCT) radiographs, along with core biopsies taken at the time of implant placement. The goal is to determine if vitamin K2 can enhance bone remodeling in socket preservation.
Who should consider this trial
Good fit: Ideal candidates are adults over 18 years old requiring extraction of single-rooted mandibular teeth.
Not a fit: Patients with systemic conditions affecting bone metabolism or those with allergies to vitamin K2 will not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could improve bone healing and density in patients undergoing tooth extraction, potentially leading to better outcomes for dental implants.
How similar studies have performed: While the use of vitamin K2 in bone healing is promising, this specific approach has not been extensively tested in prior studies, making it a novel investigation.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria:• Age \> 18 years without other age or gender restrictions. * Patients requiring extraction of mandibular single-rooted teeth. Exclusion Criteria: * • Patients with systemic conditions affecting bone metabolism. * Allergies or sensitivities to hydroxyapatite or Vitamin K2 * Untreated or residual periodontal disease; * Uncontrolled diabetes (HbA1c \> 7.5%); * Head and/or neck radiotherapy * Immunosuppressive therapy * Pregnant or nursing * Substance abuse * Treated or under treatment with intravenous amino-bisphosphonates * Patients participating in other studies, if the present protocol could not be properly followed.
Where this trial is running
Cairo, Cairo Governorate
- Cairo — Cairo, Cairo Governorate, Egypt (RECRUITING)
Study contacts
- Study coordinator: mohamed elsawaf, BDS
- Email: mohamed.elsawaf@dentistry.cu.edu.eg
- Phone: 01124145951
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Socket Preservation