Effects of Vitamin B6 on Pain Sensitivity
Testing the Effects of High-dose Vitamin B6 Supplements on Pain Thresholds and Tolerance in Healthy Adults
This study tests if taking Vitamin B6 can change how much pain healthy adults can handle and how it affects their overall well-being.
Quick facts
| Phase | Phase 1 |
|---|---|
| Study type | Interventional |
| Enrollment | 20 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | University of Reading Academic / other |
| Locations | 1 site (Reading, Berkshire) |
| Trial ID | NCT06415383 on ClinicalTrials.gov |
What this trial studies
This clinical trial investigates how Vitamin B6 supplementation influences pain thresholds and tolerance in healthy adults. Participants will receive either a high-dose Vitamin B6 or a placebo, and their responses to thermal and electrical pain stimuli will be measured. The study aims to determine the effects of a single 100mg dose and daily supplementation over a month, while also assessing related factors such as anxiety, sleep, diet, and mood. The findings could provide insights into the role of Vitamin B6 in pain management.
Who should consider this trial
Good fit: Ideal candidates are healthy adults over the age of 18 who are fluent in English.
Not a fit: Patients with chronic pain, neuropathic pain, or those on certain medications may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to new non-pharmacological approaches for managing pain.
How similar studies have performed: While the effects of Vitamin B6 on pain have been explored, this specific approach is relatively novel and has not been extensively tested.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Over the age of 18 years * Fluent speaker of English language Exclusion Criteria: * Under 18 years * Presence or history of chronic pain * Presence of neuropathic/nerve pain * Raynaud's syndrome * Using any vitamin supplementations that contain Vitamin B6 at more than the RDA, or combinations of B vitamins. * On any medication that is GABA agonistic * Any use of analgesic/anti-inflammatory medication up to 48 hours prior to any of the testing sessions. * Any heart conditions * Newly acquired tattoos on the pain stimulation site
Where this trial is running
Reading, Berkshire
- University of Reading — Reading, Berkshire, United Kingdom (Recruiting)
Study contacts
- Study coordinator: David T Field, PhD
- Email: d.t.field@reading.ac.uk
- Phone: +441183785004
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.