Effects of UVB on Young and Older Skin
Gene Expression Changes in Young and Geriatric Skin
EARLY_PHASE1 · Wright State University · NCT03932162
This study is testing how young and older skin react to UVB rays and whether a treatment can help older skin act more like younger skin.
Quick facts
| Phase | EARLY_PHASE1 |
|---|---|
| Study type | Interventional |
| Enrollment | 24 (estimated) |
| Ages | 21 Years and up |
| Sex | All |
| Sponsor | Wright State University (other) |
| Drugs / interventions | radiation |
| Locations | 1 site (Fairborn, Ohio) |
| Trial ID | NCT03932162 on ClinicalTrials.gov |
What this trial studies
This research explores how young adult skin and geriatric skin respond differently to ultraviolet B (UVB) radiation, which is known to cause skin burns and potentially lead to skin cancer. The study aims to investigate the role of insulin-like growth factor-1 (IGF-1) in this response, hypothesizing that geriatric skin treated with IGF-1 may behave more like young skin. Participants will include healthy individuals aged 21-30 and those 65 and older, with a focus on understanding the biological differences in skin aging and response to UVB exposure.
Who should consider this trial
Good fit: Ideal candidates are healthy individuals aged 21-30 or 65 and older with Fitzpatrick skin types I and II.
Not a fit: Patients with known photosensitivity, diabetes, or serious health issues may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to new treatments for skin aging and improved prevention strategies for skin cancer in older adults.
How similar studies have performed: While the specific approach of using IGF-1 in this context may be novel, studies on skin response to UVB and aging have shown varying degrees of success.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Male/Female * White skin (Fitzpatrick types I and II) * Age 21-30 or 65 and older * Able to comprehend procedures/risks Exclusion Criteria: * Known photosensitivity * Currently on photosensitizing medications * Diabetes Mellitus * History of abnormal scarring * History of skin infections * Known allergy to lidocaine local anesthetic * Pregnancy or nursing * Other serious health issues
Where this trial is running
Fairborn, Ohio
- Wright State Physicians — Fairborn, Ohio, United States (RECRUITING)
Study contacts
- Principal investigator: Jeffrey B Travers, MD, PhD — Wright State University
- Study coordinator: Manager, Clinical Research Operations
- Email: pturesearch@wrightstatephysicians.org
- Phone: 937-245-7500
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: UVB Phototherapy Burn, Insulin-like Growth Factor 1, Aging