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Clinical trial Recruiting at 1 site Early Phase 1 Interventional Ages 21 and up

Effects of UVB on Young and Older Skin

Official title: Gene Expression Changes in Young and Geriatric Skin

Run by Wright State University · NCT03932162 · Data updated 2026-11-12

This study is testing how young and older skin react to UVB rays and whether a treatment can help older skin act more like younger skin.

Quick facts

PhaseEarly Phase 1
Study typeInterventional
Ages21 Years and up
SexAll
Enrollment24 (estimated)
SponsorWright State University
Academic / other
Drugs / interventionsradiation
Locations1 site (Fairborn, Ohio)
StatusRecruiting
StartedSeptember 6, 2019
Main results expectedDecember 2025
Study endsDecember 2025
Registry record updatedFebruary 6, 2025
Trial IDNCT03932162 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates are healthy individuals aged 21-30 or 65 and older with Fitzpatrick skin types I and II.

Probably not a fit

Patients with known photosensitivity, diabetes, or serious health issues may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This research explores how young adult skin and geriatric skin respond differently to ultraviolet B (UVB) radiation, which is known to cause skin burns and potentially lead to skin cancer. The study aims to investigate the role of insulin-like growth factor-1 (IGF-1) in this response, hypothesizing that geriatric skin treated with IGF-1 may behave more like young skin. Participants will include healthy individuals aged 21-30 and those 65 and older, with a focus on understanding the biological differences in skin aging and response to UVB exposure.

Why it matters

Potential benefit: If successful, this study could lead to new treatments for skin aging and improved prevention strategies for skin cancer in older adults.

How similar studies have gone: While the specific approach of using IGF-1 in this context may be novel, studies on skin response to UVB and aging have shown varying degrees of success.

Who can join: the full rules

Show full inclusion / exclusion criteria 
Inclusion Criteria:

* Male/Female
* White skin (Fitzpatrick types I and II)
* Age 21-30 or 65 and older
* Able to comprehend procedures/risks

Exclusion Criteria:

* Known photosensitivity
* Currently on photosensitizing medications
* Diabetes Mellitus
* History of abnormal scarring
* History of skin infections
* Known allergy to lidocaine local anesthetic
* Pregnancy or nursing
* Other serious health issues

Where it's running

  • Wright State Physicians
    Fairborn, Ohio, United States     Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
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Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.