Effects of ultrasound-guided ozone and lidocaine injections for piriformis syndrome

The Effects of Ultrasound Guided Ozone and Lidocaine Injections on Pain, Functional Level and Posture in Piriformis Syndrome

Not applicable Interventional Ankara City Hospital Bilkent · NCT06130618

This study tests whether injections of ozone or lidocaine can help relieve pain and improve function in people with piriformis syndrome.

Quick facts

PhaseNot applicable
Study typeInterventional
Enrollment28 (estimated)
Ages18 Years to 80 Years
SexAll
SponsorAnkara City Hospital Bilkent Academic / other
Locations1 site (Ankara)
Trial IDNCT06130618 on ClinicalTrials.gov

What this trial studies

This clinical trial investigates the effectiveness of ultrasound-guided injections of ozone and lidocaine in patients diagnosed with piriformis syndrome, a condition characterized by sciatic nerve compression. Patients will be randomly assigned to receive either ozone or lidocaine injections, with their pain levels and functional abilities assessed at multiple time points. The study aims to evaluate pain relief and functional improvement through various measurement scales and posture analysis. A total of 28 patients will participate, with 14 in each treatment group.

Who should consider this trial

Good fit: Ideal candidates are adults over 18 with posterior thigh pain diagnosed as piriformis syndrome and a pain level of 5 or higher on a visual analog scale.

Not a fit: Patients with a history of lumbar discopathy, significant obesity, or those who have had recent corticosteroid injections may not benefit from this study.

Why it matters

Potential benefit: If successful, this treatment could provide significant pain relief and improved function for patients suffering from piriformis syndrome.

How similar studies have performed: While the specific combination of ozone and lidocaine injections is novel, similar injection therapies have shown promise in treating other forms of nerve-related pain.

Eligibility criteria

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Patients over 18 years of age
* Patients with pain in the posterior aspect of the thigh and diagnosed with piriformis through physical examination and special tests
* Knowing how to read and write Turkish
* Patients with visual analog scale ≥5

Exclusion Criteria:

* Those with a history of lumbar discopathy or a history of discopathy surgery
* BMI over ≥ 30
* Having had a corticosteroid injection within the last 3 months
* Presence of neurological deficit in the lower extremity
* Having a history of previous hip surgery
* Having progressive or non-progressive central and peripheral nervous system disease,
* Patients in pregnancy and lactation
* Use of anticoagulants

Where this trial is running

Ankara

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions Piriformis Syndrome
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.