Effects of ultra-processed foods on hunger and brain function

Elucidating the Relationship Between Ultra-Processed Food Consumption, Executive Function, and Hunger-Related Hormones

Not applicable Interventional Oklahoma State University · NCT06518863

This study is testing how eating only ultra-processed foods for three days affects hunger and brain function compared to eating unprocessed foods for three days in adults.

Quick facts

PhaseNot applicable
Study typeInterventional
Enrollment20 (estimated)
Ages18 Years to 55 Years
SexAll
SponsorOklahoma State University Academic / other
Locations1 site (Stillwater, Oklahoma)
Trial IDNCT06518863 on ClinicalTrials.gov

What this trial studies

This study investigates how a diet consisting of ultra-processed foods (UPF) affects hunger-related hormones and executive function in adults. It employs a two-arm, crossover, randomized controlled design, where participants will consume an entirely ultra-processed diet for three days followed by an entirely unprocessed diet for another three days. The aim is to assess the differences in hormonal responses and cognitive performance between the two dietary patterns.

Who should consider this trial

Good fit: Ideal candidates for this study are healthy adults aged 18-55 who can adhere to the dietary requirements.

Not a fit: Patients with chronic diseases, special dietary needs, or visual impairments may not benefit from this study.

Why it matters

Potential benefit: If successful, this study could provide insights into how dietary choices impact cognitive functions and hunger regulation.

How similar studies have performed: While there is ongoing research into the effects of diet on cognitive function, this specific approach focusing on ultra-processed versus unprocessed foods is relatively novel.

Eligibility criteria

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Adults aged 18-55
* Willing to consume an entirely ultra-processed and entirely unprocessed diet for 3 days each (6 days in total)

Exclusion Criteria:

* Chronic disease that interferes with study-related activities
* Special diet that limits adherence to the intervention diets
* Visual impairment not corrected by glasses/contacts
* Pregnant or lactating

Where this trial is running

Stillwater, Oklahoma

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions Diet Habit
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.