Effects of Tyrosol and Creatine on Endurance and Strength

The Effects of Tyrosol and Creatine on Endurance, Strength, and Fatigue Resistance in Healthy Adults: a Randomized, Double-Blind, Placebo-Controlled Trial

This study is testing whether taking tyrosol and creatine together can help healthy adults improve their endurance and strength more than taking either one alone.

Quick facts

• Phase: NA
• Study type: Interventional
• Enrollment: 60 (estimated)
• Ages: 18 Years to 50 Years
• Sex: All
• Sponsor: Applied Science & Performance Institute (industry)
• Locations: 1 site (Tampa, Florida)
• Trial ID: NCT06883292 on ClinicalTrials.gov

What this trial studies

This clinical trial investigates the impact of tyrosol and creatine on endurance, strength, and fatigue resistance in healthy adults. Over a 4-week period, participants will be randomly assigned to receive either tyrosol, creatine, a placebo, or a combination of both. The study will involve a series of tests to measure body composition, cognitive performance, and various strength metrics. The goal is to determine if the combination of tyrosol and creatine provides enhanced benefits compared to each substance alone.

Who should consider this trial

Good fit: Ideal candidates are healthy adults aged 18-50 who are physically active and meet specific fitness criteria.

Not a fit: Patients with cardiovascular, metabolic, endocrine, or renal diseases, or those with recent musculoskeletal injuries may not benefit from this study.

Why it matters

Potential benefit: If successful, this study could improve athletic performance and recovery for individuals engaged in physical activities.

How similar studies have performed: Other studies have shown positive effects of creatine on strength and endurance, but the combination with tyrosol is a novel approach.

Eligibility criteria

Inclusion Criteria:

* Healthy males or females aged 18-50
* Currently active (engaged in moderate to vigorous activity at least 2-days per week as defined by the American College of Sports Medicine Guidelines)
* Estimated VO2 max equal to or greater than the 50th percentile of the population norm for age (assessed via ACSM guidelines, 2014). The VO2 max estimation at screening will be obtained by following a non-exercise regression model validated and described by Bradshaw et al. (2005).
* Able to read and write in English
* During the study, agree not to take any other supplements that may increase muscle strength or endurance (e.g. protein formulas, creatine, amino acids, tyrosol or stimulants other than caffeine).
* Females willing to share days menstrual cycle for testing purposes as shifts in hormone levels may, potentially, affect testing

Exclusion Criteria:

* Known diagnosis of any cardiovascular, metabolic, endocrine, or renal disease
* Recent musculoskeletal injury (\<3-months)
* Recent orthopaedic surgery (\<12-months)
* History or current malignancy
* Previous gastrointestinal surgery within the past 12 months
* Regular smoker
* Regular drinker (\>14 drinks per week)
* Current use (within the past 4 weeks) of creatine supplements
* Current use (within past 3 months) of Tyrosol supplementation
* Current use of dietary supplements that may enhance mitochondrial function, muscle hypertrophy, or muscle strength (e.g. protein formulas, creatine, amino acids, tyrosol, etc.).
* Current use of prescription medications that may influence adaptation to exercise (hormone therapies, peptides, etc.)
* Female subjects who do not test negative on a urine pregnancy test or are lactating.

Where this trial is running

Tampa, Florida

• Applied Science & Performance Institute — Tampa, Florida, United States (RECRUITING)

Study contacts

• Principal investigator: Eric Sikorski, PhD — Applied Science and Performance Institute
• Study coordinator: Eric Sikorski, PhD

Conditions: Tyrosol, Creatine, Endurance Performance, Cognition, tyrosol, creatine, muscle strength, muscle endurance