Effects of Two MAP Targets on Eye Blood Flow During Rhinoplasty
Official title: Effects of Different Mean Arterial Pressure Targets on Ocular Perfusion and OCTA-Derived Optic Nerve Head Microvasculature During Controlled Hypotension in Rhinoplasty: A Prospective Randomized Controlled Trial
Run by Hitit University · NCT07832305 · Data updated 2026-11-12
This study tests whether using a lower vs. slightly higher mean arterial pressure during rhinoplasty affects eye blood flow and optic nerve perfusion in adults undergoing elective nose surgery.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 60 (estimated) |
| Sponsor | Hitit University Academic / other |
| Locations | 1 site (Çorum) |
| Status | Recruiting |
| Started | September 20, 2026 |
| Main results expected | December 1, 2026 |
| Study ends | December 15, 2026 |
| Registry record updated | October 14, 2026 |
| Trial ID | NCT07832305 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults 18-50 undergoing elective rhinoplasty or septorhinoplasty, ASA I-II, without significant ocular or systemic disease.
✕Probably not a fit
Individuals with preexisting eye diseases or intolerance to controlled hypotension may not benefit and could be at risk.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This randomized trial compares two controlled hypotension targets during general anesthesia for rhinoplasty or septorhinoplasty. Sixty adults without major eye disease are randomized to target MAP 50-60 mmHg or 60-70 mmHg, with ophthalmic measurements taken perioperatively to estimate ocular perfusion pressure and assess microvascular changes with OCTA. Primary outcome is the change in peripapillary vessel density between groups, with secondary assessment of optic nerve head microvasculature and intraoperative ocular parameters. Both groups receive standardized anesthesia, while the ophthalmologist evaluating postoperative OCTA remains blinded to group assignment. The study addresses whether lower MAP could compromise ocular perfusion or whether higher MAP better preserves ocular microcirculation during controlled hypotension.
Why it matters
Potential benefit: If successful, the findings could guide safer MAP targets to protect eye perfusion during rhinoplasty.
How similar studies have gone: Prior evidence suggests perfusion changes can occur with varied MAP, but this exact targeted comparison during rhinoplasty is relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age 18-50 years * Scheduled for elective rhinoplasty or septorhinoplasty * American Society of Anesthesiologists (ASA) physical status I-II * Willing and able to provide written informed consent Exclusion Criteria: * History of glaucoma, retinal disease, optic neuropathy, or other significant ophthalmologic disease * Previous ocular surgery * High myopia * Uncontrolled hypertension, diabetes mellitus, or other serious systemic disease * ASA physical status III or higher * Development of severe intraoperative hemodynamic instability * Massive intraoperative bleeding * Inadequate OCTA image quality for analysis * Pregnancy * Refusal to participate or withdrawal of consent
Where it's running
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Hitit university
Çorum, Turkey (Türkiye) Recruiting
Study contacts
- Study coordinator: Sibel ÖNEN ÖZDEMİR
- Email: sibelonen89@gmail.com
- Phone: +905442892194
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.