Effects of THC on stress memories
Official title: Effects of Drugs on Stress Memories
Run by University of Chicago · NCT06471647 · Data updated 2026-05-14
This study is no longer in our active list. It may have stopped recruiting or finished. The details below are as of 2026-05-14 and are kept for reference. Check ClinicalTrials.gov for its current status, or see similar studies below.
This study tests if low doses of THC can help people feel less affected by stressful memories.
Quick facts
| Phase | Early Phase 1 |
|---|---|
| Study type | Interventional |
| Ages | 18 Years to 35 Years |
| Sex | All |
| Enrollment | 48 (estimated) |
| Sponsor | University of Chicago Academic / other |
| Locations | 1 site (Chicago, Illinois) |
| Trial ID | NCT06471647 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are healthy adults aged 18-35 with a BMI between 19-29 who have some prior experience with cannabis.
✕Probably not a fit
Patients with severe substance use disorders, a history of psychosis, or those who are pregnant will not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study investigates how low doses of delta-9-tetrahydrocannabinol (THC) influence memories related to stress. It employs a randomized, placebo-controlled design with 48 healthy participants who will be assigned to receive either THC or a placebo. Participants will undergo a stress-inducing procedure and then have their physiological and psychological responses measured during a subsequent memory retrieval session. The goal is to determine if THC can reduce the impact of negative memories associated with stress.
Why it matters
Potential benefit: If successful, this study could provide insights into using THC as a therapeutic option for managing stress-related memories.
How similar studies have gone: While there is evidence suggesting cannabinoids can reduce stress responses, this specific approach to studying THC's effects on stress memories is relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * 18-35 y/o * BMI 19-29 kg/m2 * some prior experience with cannabis (used at least 4 times, no adverse experiences, and current use no more than once a week) Exclusion Criteria: * Current severe substance use disorder * history of psychosis or mania * Lack of English fluency * Current DSM IV Axis I disorder * Abnormal EKG * Daily use of medications outside of contraception, * Women who are pregnant or trying to become pregnant
Where it's running
-
University of Chicago
Chicago, Illinois, United States Recruiting
Study contacts
- Principal investigator: Harriet de Wit — University of Chicago
- Study coordinator: Hanna Molla
- Email: hmolla@uchicago.edu
- Phone: 773-702-3560
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.