Effects of THC on stress memories
Effects of Drugs on Stress Memories
EARLY_PHASE1 · University of Chicago · NCT06471647
This study tests if low doses of THC can help people feel less affected by stressful memories.
Quick facts
| Phase | EARLY_PHASE1 |
|---|---|
| Study type | Interventional |
| Enrollment | 48 (estimated) |
| Ages | 18 Years to 35 Years |
| Sex | All |
| Sponsor | University of Chicago (other) |
| Locations | 1 site (Chicago, Illinois) |
| Trial ID | NCT06471647 on ClinicalTrials.gov |
What this trial studies
This study investigates how low doses of delta-9-tetrahydrocannabinol (THC) influence memories related to stress. It employs a randomized, placebo-controlled design with 48 healthy participants who will be assigned to receive either THC or a placebo. Participants will undergo a stress-inducing procedure and then have their physiological and psychological responses measured during a subsequent memory retrieval session. The goal is to determine if THC can reduce the impact of negative memories associated with stress.
Who should consider this trial
Good fit: Ideal candidates are healthy adults aged 18-35 with a BMI between 19-29 who have some prior experience with cannabis.
Not a fit: Patients with severe substance use disorders, a history of psychosis, or those who are pregnant will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could provide insights into using THC as a therapeutic option for managing stress-related memories.
How similar studies have performed: While there is evidence suggesting cannabinoids can reduce stress responses, this specific approach to studying THC's effects on stress memories is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * 18-35 y/o * BMI 19-29 kg/m2 * some prior experience with cannabis (used at least 4 times, no adverse experiences, and current use no more than once a week) Exclusion Criteria: * Current severe substance use disorder * history of psychosis or mania * Lack of English fluency * Current DSM IV Axis I disorder * Abnormal EKG * Daily use of medications outside of contraception, * Women who are pregnant or trying to become pregnant
Where this trial is running
Chicago, Illinois
- University of Chicago — Chicago, Illinois, United States (RECRUITING)
Study contacts
- Principal investigator: Harriet de Wit — University of Chicago
- Study coordinator: Hanna Molla
- Email: hmolla@uchicago.edu
- Phone: 773-702-3560
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Delta-9-tetrahydrocannabinol, Stress