Effects of tDCS on cognition in mild cognitive impairment

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial evaluates the effectiveness of transcranial direct current stimulation (tDCS) on cognitive skills in patients with mild cognitive impairment (MCI) related to Alzheimer's and Parkinson's diseases. The study involves a multicenter, randomized, controlled design where participants receive anodal tDCS applied to specific brain regions over 10 sessions within 14 days. Cognitive outcomes will be assessed using neurocognitive tests and brain connectivity will be analyzed through fMRI and EEG at various time points. The goal is to explore the potential cognitive benefits of tDCS and its implications for understanding MCI and Parkinson's disease.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Providing an informed consent;
2. Literate and between 45-80 years of age;
3. 60 females and 60 males;
4. Diagnosed with PD based on criteria suggested by UK Parkinson's Disease Society, Brain Bank and PD-MCI in accordance with the diagnostic criteria suggestions by Litvan;
5. Diagnosed with aMCI based on diagnosis criteria (CDR\>0.5) suggested by Petersen;
6. On a stable pharmacological treatment minimum for one month with no washout period.

Exclusion Criteria:

* Illiterate or education level less than primary school
* Having an existing and/or prior neurological disease; psychiatric disease or head trauma; and/or irreversible hearing or sight problems or other medical illness (e.g. diabetes mellitus, hypertension);
* Exhibiting signs of dementia for PD group ;
* Having medical issues that prevent undergoing fMRI or for tDCS application.

Where it's running

• Alanya Alaaddin Keykubat Üniversitesi
  Antalya, Alanya, Turkey (Türkiye) Recruiting

Study contacts

• Study coordinator: Burak Yuluğ, Prof. DR. MD
• Email: burakyulug@gmail.com
• Phone: +90 242 510 6135

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.