Effects of Sufentanil on Blood Pressure During Surgery
Effects of Sufentanil on the Intraoperative Hemodynamic Parameters in Patients Undergoing Extracranial-intracranial Bypass Surgery: a Prospective Randomized Controlled Trial
This study tests whether using sufentanil instead of remifentanil during surgery helps keep blood pressure stable in patients having a specific type of brain surgery.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 92 (estimated) |
| Ages | 19 Years and up |
| Sex | All |
| Sponsor | Seoul National University Hospital Academic / other |
| Locations | 1 site (Seongnam-si, Gyeonggi-do) |
| Trial ID | NCT06091904 on ClinicalTrials.gov |
What this trial studies
This clinical trial investigates the impact of sufentanil compared to remifentanil on intraoperative hemodynamics in patients undergoing elective extracranial-intracranial bypass surgery. A total of 92 patients will be randomly assigned to receive either sufentanil or remifentanil during the procedure. The study aims to assess how these medications influence blood pressure and overall hemodynamic stability during surgery.
Who should consider this trial
Good fit: Ideal candidates for this study are adults over 18 years old who are scheduled for elective extracranial-intracranial bypass surgery and classified as American Society of Anesthesiologists grade 1, 2, or 3.
Not a fit: Patients who are pregnant, have severe respiratory insufficiency, or are classified as American Society of Anesthesiologists grade 4 will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved management of intraoperative hypotension, enhancing patient safety and outcomes during surgery.
How similar studies have performed: Other studies have shown varying success with similar approaches in managing intraoperative hemodynamics, but this specific comparison of sufentanil and remifentanil is novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients who undergo elective extracranial-intracranial bypass surgery * American Society of Anesthesiologists grade 1,2,3 * Age \> 18 years old Exclusion Criteria: * Refuse to participate to the study * American Society of Anesthesiologists grade 4 * Body Mass Index \< 18.5 kg/m2 or \> 35 kg/m2 * Allergic history of opioid * pregnant * MAO Inhibitor user * Severe respiratory insufficiency
Where this trial is running
Seongnam-si, Gyeonggi-do
- Seoul National University Bundang Hospital — Seongnam-si, Gyeonggi-do, South Korea (Recruiting)
Study contacts
- Principal investigator: Chang-Hoon Koo — Seoul National University Bundang Hospital
- Study coordinator: Chang-Hoon Koo
- Email: vollock9@gmail.com
- Phone: +821085098841
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.