Clinical trial Recruiting at 1 site Interventional Ages 19 and up

Effects of Sufentanil on Blood Pressure During Surgery

Official title: Effects of Sufentanil on the Intraoperative Hemodynamic Parameters in Patients Undergoing Extracranial-intracranial Bypass Surgery: a Prospective Randomized Controlled Trial

Run by Seoul National University Hospital · NCT06091904 · Data updated 2026-11-12

This study tests whether using sufentanil instead of remifentanil during surgery helps keep blood pressure stable in patients having a specific type of brain surgery.

Quick facts

Study typeInterventional
Ages19 Years and up
SexAll
Enrollment92 (estimated)
SponsorSeoul National University Hospital
Academic / other
Locations1 site (Seongnam-si, Gyeonggi-do)
StatusRecruiting
StartedNovember 24, 2023
Main results expectedNovember 1, 2025
Study endsNovember 1, 2026
Registry record updatedSeptember 16, 2025
Trial IDNCT06091904 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates for this study are adults over 18 years old who are scheduled for elective extracranial-intracranial bypass surgery and classified as American Society of Anesthesiologists grade 1, 2, or 3.

Probably not a fit

Patients who are pregnant, have severe respiratory insufficiency, or are classified as American Society of Anesthesiologists grade 4 will not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial investigates the impact of sufentanil compared to remifentanil on intraoperative hemodynamics in patients undergoing elective extracranial-intracranial bypass surgery. A total of 92 patients will be randomly assigned to receive either sufentanil or remifentanil during the procedure. The study aims to assess how these medications influence blood pressure and overall hemodynamic stability during surgery.

Why it matters

Potential benefit: If successful, this study could lead to improved management of intraoperative hypotension, enhancing patient safety and outcomes during surgery.

How similar studies have gone: Other studies have shown varying success with similar approaches in managing intraoperative hemodynamics, but this specific comparison of sufentanil and remifentanil is novel.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Patients who undergo elective extracranial-intracranial bypass surgery
* American Society of Anesthesiologists grade 1,2,3
* Age \> 18 years old

Exclusion Criteria:

* Refuse to participate to the study
* American Society of Anesthesiologists grade 4
* Body Mass Index \< 18.5 kg/m2 or \> 35 kg/m2
* Allergic history of opioid
* pregnant
* MAO Inhibitor user
* Severe respiratory insufficiency

Where it's running

  • Seoul National University Bundang Hospital
    Seongnam-si, Gyeonggi-do, South Korea
    Recruiting

Study contacts

  • Principal investigator: Chang-Hoon Koo — Seoul National University Bundang Hospital
  • Study coordinator: Chang-Hoon Koo
  • Email: vollock9@gmail.com
  • Phone: +821085098841

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.