Effects of Sufentanil on Blood Pressure During Surgery
Official title: Effects of Sufentanil on the Intraoperative Hemodynamic Parameters in Patients Undergoing Extracranial-intracranial Bypass Surgery: a Prospective Randomized Controlled Trial
Run by Seoul National University Hospital · NCT06091904 · Data updated 2026-11-12
This study tests whether using sufentanil instead of remifentanil during surgery helps keep blood pressure stable in patients having a specific type of brain surgery.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 19 Years and up |
| Sex | All |
| Enrollment | 92 (estimated) |
| Sponsor | Seoul National University Hospital Academic / other |
| Locations | 1 site (Seongnam-si, Gyeonggi-do) |
| Status | Recruiting |
| Started | November 24, 2023 |
| Main results expected | November 1, 2025 |
| Study ends | November 1, 2026 |
| Registry record updated | September 16, 2025 |
| Trial ID | NCT06091904 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are adults over 18 years old who are scheduled for elective extracranial-intracranial bypass surgery and classified as American Society of Anesthesiologists grade 1, 2, or 3.
✕Probably not a fit
Patients who are pregnant, have severe respiratory insufficiency, or are classified as American Society of Anesthesiologists grade 4 will not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This clinical trial investigates the impact of sufentanil compared to remifentanil on intraoperative hemodynamics in patients undergoing elective extracranial-intracranial bypass surgery. A total of 92 patients will be randomly assigned to receive either sufentanil or remifentanil during the procedure. The study aims to assess how these medications influence blood pressure and overall hemodynamic stability during surgery.
Why it matters
Potential benefit: If successful, this study could lead to improved management of intraoperative hypotension, enhancing patient safety and outcomes during surgery.
How similar studies have gone: Other studies have shown varying success with similar approaches in managing intraoperative hemodynamics, but this specific comparison of sufentanil and remifentanil is novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients who undergo elective extracranial-intracranial bypass surgery * American Society of Anesthesiologists grade 1,2,3 * Age \> 18 years old Exclusion Criteria: * Refuse to participate to the study * American Society of Anesthesiologists grade 4 * Body Mass Index \< 18.5 kg/m2 or \> 35 kg/m2 * Allergic history of opioid * pregnant * MAO Inhibitor user * Severe respiratory insufficiency
Where it's running
-
Seoul National University Bundang Hospital
Seongnam-si, Gyeonggi-do, South Korea Recruiting
Study contacts
- Principal investigator: Chang-Hoon Koo — Seoul National University Bundang Hospital
- Study coordinator: Chang-Hoon Koo
- Email: vollock9@gmail.com
- Phone: +821085098841
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Remimazolam vs propofol for stable blood pressure during thoracic/abdominal endovascular aortic repair
This trial tests whether remimazolam keeps blood pressure steadier than propofol during TEVAR or EVAR in adults.
-
Remimazolam vs. Propofol for Maintaining Anesthesia During Major Liver Resection
This study tests whether remimazolam keeps blood pressure steadier than propofol during major liver surgery in adults.
-
Remimazolam versus Midazolam for anesthesia induction in older adults
This observational study compares remimazolam and midazolam when inducing anesthesia in people aged 65 and older undergoing elective non-cardiac surgery to see which provides better stability and safety.
-
Keep blood pressure at 85 or more during surgery to prevent delirium in older adults with hypertension
In older adults with high blood pressure undergoing non-heart surgery, researchers test if keeping mean arterial pressure at or above 85 mmHg during surgery reduces postoperative delirium.
-
Internal Jugular Vein Collapsibility to Predict Hypotension in Older Adults Undergoing Laparoscopic Colorectal Surgery
This study tests whether measuring the internal jugular vein collapsibility index can predict intraoperative hypotension in patients aged 60 and older undergoing elective laparoscopic colorectal surgery.
-
Can neck vein ultrasound predict low blood pressure and kidney injury during abdominal surgery?
This observational study tests whether ultrasound measurements of the internal jugular vein can help predict low blood pressure during anesthesia induction and possible kidney injury after abdominal surgery.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.