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Clinical trial Recruiting at 1 site Interventional Ages 60 to 95

Effects of Statins on Atrial Fibrillation After Aortic Valve Surgery

Official title: Post-Operative Atrial Fibrillation After Surgical Aortic Valve Replacement and the Influence of Statins - Randomized Controlled Trial

Run by Odense University Hospital · NCT05062239 · Data updated 2026-11-12

This study tests whether taking statins before and after aortic valve surgery can help prevent heart rhythm problems in patients undergoing the procedure.

More Atrial Fibrillation trials

Quick facts

Study typeInterventional
Ages60 Years to 95 Years
SexAll
Enrollment100 (estimated)
SponsorOdense University Hospital
Academic / other
Locations1 site (Odense)
StatusRecruiting
StartedApril 1, 2022
Main results expectedFebruary 1, 2027
Study endsFebruary 1, 2027
Registry record updatedApril 23, 2025
Trial IDNCT05062239 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates are patients over 60 years old undergoing elective solitary surgical aortic valve replacement who have been on statin therapy for at least 7 days in the past 3 months.

Probably not a fit

Patients with a prior history of atrial fibrillation or those with significant hepatic or renal dysfunction may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the impact of statin treatment on the occurrence of postoperative atrial fibrillation (POAF) in patients undergoing surgical aortic valve replacement (SAVR). It is a randomized controlled trial comparing continuous statin treatment with a discontinuation period of 7 to 14 days before surgery until 30 days post-operation. The trial aims to enroll 100 patients and will monitor for complications such as POAF and other cardiac issues during hospitalization. Continuous ECG monitoring will be utilized to detect AF, and patient eligibility will be assessed through a multidisciplinary team approach.

Why it matters

Potential benefit: If successful, this study could lead to improved management strategies for preventing postoperative atrial fibrillation in cardiac surgery patients.

How similar studies have gone: While the approach of using statins in this context is being explored, similar studies have shown mixed results, indicating that this area is still under investigation.

Who can join: the full rules

Show full inclusion / exclusion criteria 
Inclusion Criteria:

1. Patients undergoing elective solitary SAVR with bioprosthesis
2. Patients who are in sinus rhythm and not taking any anti-arrhythmic medication, other than beta-adrenergic blocking agents, at the time of surgery
3. In treatment with HMG-CoA reductase inhibitors in the past 3 months and of at least 7 days
4. Age \>60 years
5. Willingness and provision of informed consent to be randomized

Exclusion Criteria:

1. Prior history of atrial fibrillation
2. Prior history of cardiac surgery
3. Hepatic dysfunction (Alanin-aminotransferase more than twice the upper limit)
4. Creatinine \>200 µmol/L

Where it's running

  • Odense University Hospital
    Odense, Denmark     Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
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Postoperative Atrial Fibrillation 8Odense University Hospital 71
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.