Effects of sleep restriction on individuals with a family history of hypertension
Sleep Restriction and Parental History of Hypertension
This study tests how not getting enough sleep affects young adults with a family history of high blood pressure compared to those without such a background.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 44 (estimated) |
| Ages | 18 Years to 35 Years |
| Sex | All |
| Sponsor | Mayo Clinic Academic / other |
| Locations | 1 site (Rochester, Minnesota) |
| Trial ID | NCT06482814 on ClinicalTrials.gov |
What this trial studies
This study investigates how partial sleep deprivation affects individuals whose parents have high blood pressure compared to those with normal blood pressure backgrounds. Healthy adults aged 18-35 will participate in the study, undergoing interventions that include periods of sleep restriction and normal sleep. The goal is to understand the relationship between sleep patterns and hypertension risk in individuals with a familial predisposition. Participants must have a documented history of normal sleep duration and meet specific health criteria.
Who should consider this trial
Good fit: Ideal candidates are healthy adults aged 18-35 with a family history of hypertension and normal sleep duration.
Not a fit: Patients outside the age range, with significant medical conditions, or those with a history of hypertension in their biological parents may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could provide insights into how sleep patterns influence hypertension risk, potentially leading to better prevention strategies.
How similar studies have performed: While the specific approach of this study may be novel, previous research has indicated a link between sleep patterns and hypertension, suggesting potential for success.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria * Healthy adults aged 18-35 years * Absence of any significant medical or psychiatric disease (as per the investigators' judgment) * Nonsmoker * Nonpregnant * History of normal sleep duration (reported average sleep duration between 7-9 hours/night and no habitual napping) * Hypertension status information available for both biological parents * Ability to understand study procedures and to comply with them for the entire length of the study * Ability to understand English and provide informed consent Exclusion Criteria * Age \<18 or \>35 years * Body mass index \<18.5 or ≥30 kg/m2 * Pregnant or lactating * Unable to determine history of HTN in participant's biological parents or subject being adopted * Use of tobacco, vaping, marijuana products or other drugs * Excessive caffeine consumption (\>400 mg/day) * Excessive alcohol consumption (\>7 drinks/week for women, \>14 drinks/week for men) * Office SBP/DBP ≥130/80 mmHg * Daytime ambulatory SBP/DBP ≥130/80 mmHg * Fasting glucose ≥126 mg/dl * Glomerular filtration rate \<60 mL/min/BSA * History of significant medical or psychiatric disorders (as per the investigators' judgment) * Regular use of prescription medications other than contraceptives * Use of melatonin supplements or any other over-the-counter sleep aid * Moderate-to-severe sleep disordered breathing (apnea/hypopnea index, AHI ≥15) or mild sleep disordered breathing (AHI 5-15) with daytime sleepiness (Epworth Sleepiness Scale \>10) * Moderate-to-severe insomnia (Insomnia Severity Index \>14) * Restless leg syndrome (as per the Cambridge-Hopkins questionnaire) * Excessive daytime sleepiness (Epworth Sleepiness Scale \>15) * Extreme chronotype (Morningness-Eveningness Questionnaire \>69 or \<31) * Night shift work * Ongoing participation in other research studies (as per the investigators' judgment) * Any other medical, geographic, or social factor making study participation impractical * Not English-speaking and/or inability to provide informed consent * Exclusionary for blood draws: hemoglobin \<11.6 g/dL in women / \<13.2 g/dL in men; participants with measured hemoglobin levels below these thresholds will be allowed to continue participate in study tests and procedures not involving blood draws.
Where this trial is running
Rochester, Minnesota
- Mayo Clinic in Rochester — Rochester, Minnesota, United States (Recruiting)
Study contacts
- Principal investigator: Naima Covassin, Ph.D — Mayo Clinic
- Study coordinator: Sabah Munir
- Email: Munir.Sabah@mayo.edu
- Phone: (507)255-0151
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.