Effects of sleep restriction on appetite and gastric emptying

The Impact of Sleep Restriction on Gastric Emptying, Appetite and Energy Intake in Healthy Individuals

This study tests how not getting enough sleep affects hunger and how quickly food leaves the stomach in healthy adults.

Quick facts

• Phase: NA
• Study type: Interventional
• Enrollment: 12 (estimated)
• Ages: 18 Years to 45 Years
• Sex: All
• Sponsor: Northumbria University (other)
• Locations: 1 site (Newcastle Upon Tyne, Tyne And Wear)
• Trial ID: NCT05953285 on ClinicalTrials.gov

What this trial studies

This study investigates how partial sleep deprivation affects blood markers and subjective measures of appetite, as well as its impact on gastric emptying. It employs a within-subjects, randomized crossover design over approximately 5 to 11 weeks. Participants will undergo screening and data collection, including the use of an actigraphy device to monitor sleep patterns. The study aims to provide insights into the relationship between sleep and appetite regulation in healthy adults.

Who should consider this trial

Good fit: Ideal candidates are healthy adults aged 18 to 45 who typically sleep between 7 to 9 hours.

Not a fit: Patients who are pregnant, smokers, or have excessive alcohol or caffeine consumption may not benefit from this study.

Why it matters

Potential benefit: If successful, this study could lead to better understanding and management of obesity through sleep-related interventions.

How similar studies have performed: While the specific approach may be novel, previous studies have indicated that sleep deprivation can influence appetite and metabolic processes.

Eligibility criteria

Inclusion

1. Healthy (As assessed with medical screening questionnaire)
2. Self-reported habitual bedtimes between 7 to 9 hours (As assessed with the Pittsburgh sleep quality index)
3. Between the ages of 18 to 45

Exclusion

1. Participants will also be excluded from participation if they are pregnant.
2. Current smokers
3. Excessive alcohol (\>2 drinks per day)
4. Excessive caffeine (\>300mg per day)
5. Musculoskeletal injury.
6. Shift work during the past 4 weeks
7. Travel across more than one time zones during the past 4 weeks.
8. An indication of having a depressed mood (As assessed by a score on the Centre for Epidemiologic Studies of Depression scale above 16).
9. Moderately or highly physically active, as determined by the International Physical Activity Questionnaire (IPAQ) short form.
10. Excessive daytime sleepiness as measured by the Epworth Sleepiness Scale (Score \> 10) (ESS) (Hart et al., 2015).
11. Participants will also be considered ineligible if they achieve a score indicative of narcolepsy or chronic insomnia, as assessed through the Pittsburgh Sleep Quality Index \[PSQI\] (Score \> 5) (Hart et al., 2015).
12. Participants must achieve a score \< 50 on the Food Craving Questionnaire-Trait-reduced (FCQ-T-r), which has been shown to discriminated between individuals with and without "food addiction" with high sensitivity (85%) and specificity (93%) (Meule et al., 2014).

Where this trial is running

Newcastle Upon Tyne, Tyne And Wear

• Northumbria university — Newcastle Upon Tyne, Tyne And Wear, United Kingdom (RECRUITING)

Study contacts

• Study coordinator: Victoria McIver, PhD

Conditions: Obesity, Sleep restriction, Gastrointestinal function, Appetite regulation, Gut hormones, Hedonic appetite