Effects of Sevoflurane Anesthesia on Spatial Memory in Adults
Study of the Effect of Sevoflurane General Anesthetic on Spatial Memory in Humans
This study is testing how sevoflurane anesthesia during gallbladder surgery affects memory in adults by having them complete a virtual maze before and after the procedure.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 22 (estimated) |
| Ages | 30 Years to 50 Years |
| Sex | All |
| Sponsor | University of Chile Academic / other |
| Locations | 2 sites (Santiago, RM and 1 other locations) |
| Trial ID | NCT05991817 on ClinicalTrials.gov |
What this trial studies
This observational study aims to investigate how general anesthesia with sevoflurane affects spatial memory in adults undergoing elective laparoscopic cholecystectomy. Participants will complete a virtual maze test and have plasma samples collected before and after surgery to measure inflammatory cytokines. The study seeks to establish a correlation between the inflammatory response induced by surgery and changes in spatial memory performance. By understanding these effects, the research hopes to shed light on postoperative cognitive dysfunction and its underlying mechanisms.
Who should consider this trial
Good fit: Ideal candidates are adults aged 30 to 50 who are scheduled for elective laparoscopic cholecystectomy.
Not a fit: Patients with visual or hearing difficulties, neuropsychiatric disorders, or those on centrally acting medications may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved understanding and management of postoperative cognitive dysfunction in patients undergoing surgery.
How similar studies have performed: While the effects of anesthesia on cognitive function have been studied, this specific approach focusing on spatial memory and inflammatory markers is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Candidate for elective laparoscopic surgery of cholecystectomy. * Age 30 to 50 years. Exclusion Criteria: * Visual or hearing difficulties. * Malignant hyperthermia. * Being treated with centrally acting drugs, such as anxiolytics, antidepressants, antipsychotics, anticonvulsants, anticholinergics, and first-generation antihistamines. * Present a disorder of the sphere of neuropsychiatry * Substance abuse disorder.
Where this trial is running
Santiago, RM and 1 other locations
- Centro de Investigación Cínica Avanzada (CICA), Hospital Clinico de la Universidad de Chile — Santiago, Rm, Chile (Recruiting)
- Hospital Clinico de la Universidad de Chile — Santiago, Rm, Chile (Recruiting)
Study contacts
- Principal investigator: Khaleed Etchegaray — University of Chile
- Study coordinator: Antonello Penna, MD, PhD
- Email: apenna@uchile.cl
- Phone: +56956766623
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.