Effects of Sevoflurane Anesthesia on Spatial Memory in Adults
Official title: Study of the Effect of Sevoflurane General Anesthetic on Spatial Memory in Humans
Run by University of Chile · NCT05991817 · Data updated 2026-11-12
This study is testing how sevoflurane anesthesia during gallbladder surgery affects memory in adults by having them complete a virtual maze before and after the procedure.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 30 Years to 50 Years |
| Sex | All |
| Enrollment | 22 (estimated) |
| Sponsor | University of Chile Academic / other |
| Locations | 2 sites (Santiago, RM and 1 other locations) |
| Status | Recruiting |
| Started | August 14, 2023 |
| Main results expected | November 30, 2025 |
| Study ends | December 30, 2025 |
| Registry record updated | November 20, 2025 |
| Trial ID | NCT05991817 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults aged 30 to 50 who are scheduled for elective laparoscopic cholecystectomy.
✕Probably not a fit
Patients with visual or hearing difficulties, neuropsychiatric disorders, or those on centrally acting medications may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study aims to investigate how general anesthesia with sevoflurane affects spatial memory in adults undergoing elective laparoscopic cholecystectomy. Participants will complete a virtual maze test and have plasma samples collected before and after surgery to measure inflammatory cytokines. The study seeks to establish a correlation between the inflammatory response induced by surgery and changes in spatial memory performance. By understanding these effects, the research hopes to shed light on postoperative cognitive dysfunction and its underlying mechanisms.
Why it matters
Potential benefit: If successful, this study could lead to improved understanding and management of postoperative cognitive dysfunction in patients undergoing surgery.
How similar studies have gone: While the effects of anesthesia on cognitive function have been studied, this specific approach focusing on spatial memory and inflammatory markers is relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Candidate for elective laparoscopic surgery of cholecystectomy. * Age 30 to 50 years. Exclusion Criteria: * Visual or hearing difficulties. * Malignant hyperthermia. * Being treated with centrally acting drugs, such as anxiolytics, antidepressants, antipsychotics, anticonvulsants, anticholinergics, and first-generation antihistamines. * Present a disorder of the sphere of neuropsychiatry * Substance abuse disorder.
Where it's running
-
Centro de Investigación Cínica Avanzada (CICA), Hospital Clinico de la Universidad de Chile
Santiago, Rm, Chile Recruiting -
Hospital Clinico de la Universidad de Chile
Santiago, Rm, Chile Recruiting
Study contacts
- Principal investigator: Khaleed Etchegaray — University of Chile
- Study coordinator: Antonello Penna, MD, PhD
- Email: apenna@uchile.cl
- Phone: +56956766623
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.