Effects of saline temperature on pain after wisdom tooth removal

Does Saline Irrigation At Different Temperatures Affect Pain, Edema, and Trismus After Impacted Third Molar Surgery: a Clinical Trial

Not applicable Interventional Armed Forces Institute of Dentistry, Pakistan · NCT06741696

This study tests whether using warm or cold saline during wisdom tooth removal can help reduce pain and improve recovery for patients.

Quick facts

PhaseNot applicable
Study typeInterventional
Enrollment48 (estimated)
AgesN/A to 59 Years
SexAll
SponsorArmed Forces Institute of Dentistry, Pakistan Academic / other
Locations1 site (Rawalpindi, Punjab Province)
Trial IDNCT06741696 on ClinicalTrials.gov

What this trial studies

This clinical trial investigates the impact of saline irrigation at different temperatures on postoperative pain following the surgical extraction of third molars. A total of 48 healthy patients with bilaterally asymptomatic mandibular third molars were randomly assigned to receive either warm or cold saline during their procedure. Pain levels, swelling, and trismus were assessed at multiple time points post-surgery, and the amount of analgesics consumed was recorded. The study employs various statistical analyses to evaluate the effectiveness of the saline temperature on pain management.

Who should consider this trial

Good fit: Ideal candidates are healthy individuals with bilaterally asymptomatic impacted mandibular third molars who can comply with follow-up requirements.

Not a fit: Patients with significant systemic diseases, poor oral hygiene, or those who have recently used analgesics or antibiotics may not benefit from this study.

Why it matters

Potential benefit: If successful, this study could lead to improved pain management strategies for patients undergoing third molar surgery.

How similar studies have performed: While similar studies on postoperative pain management exist, the specific focus on saline temperature in this context is relatively novel.

Eligibility criteria

Show full inclusion / exclusion criteria
Inclusion Criteria:1. Patients who met the requirements of the study, such as attending follow-up sessions and signing the informed consent. 2. Patients with bilateral mandibular asymptomatic vertical third molar teeth with impaction of Class I, level C.22 3. Patients who did not have any significant medical diseases or drug use, were not pregnant, had no allergy, and did not smoke.

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Exclusion Criteria:

1 Patients with complicating systemic disease ( American Society of Anesthesiologists : 3- 6). 2. Patients who have second molars with severe periodontal defect or deep periodontal pocket (probing depth \>4 mm). 3. Patients with poor oral hygiene. 4. Patients with a history of using analgesics 12 hours ago or antibiotics 1 month before. 5. The presence of cysts or tumors around the impacted third molar.

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Where this trial is running

Rawalpindi, Punjab Province

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions Post Operative Pain, Acute3rd molar surgery, saline irrigation at different temperatures
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.