Effects of rTMS on motor function in stroke patients
Effects of Repetitive Transcranial Magnetic Stimulation (rTMS) on Upper Extremity Motor Function in Stroke Patients
This study is testing if a new brain stimulation technique can help improve arm and hand movement in people who have had a stroke.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 150 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Lithuanian University of Health Sciences Academic / other |
| Locations | 1 site (Kaunas) |
| Trial ID | NCT05646134 on ClinicalTrials.gov |
What this trial studies
This clinical trial evaluates the impact of repetitive transcranial magnetic stimulation (rTMS) on upper extremity motor function in patients who have suffered an ischemic stroke. Participants will undergo 10 sessions of rTMS over two weeks, with random assignment to either low-frequency, high-frequency, or sham stimulation groups. The effectiveness of the treatment will be assessed using various motor function tests before and after the intervention. The study aims to determine if rTMS can significantly improve motor function compared to sham treatment.
Who should consider this trial
Good fit: Ideal candidates are individuals who have experienced an ischemic stroke within the last month and have upper limb motor deficits.
Not a fit: Patients with severe cognitive impairments or those with contraindications to magnetic stimulation will not benefit from this study.
Why it matters
Potential benefit: If successful, this treatment could enhance motor recovery in stroke patients, improving their quality of life.
How similar studies have performed: Previous studies have shown promising results for rTMS in stroke rehabilitation, indicating potential for success in this approach.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Ischemic stroke of the middle cerebral artery, confirmed by instrumental tests (CT, MRI). 2. Acute hemiplegia/hemiparesis, hand motor deficit, muscle strength ≤ 4 points (as assessed by the Lovett scale). 3. Time after the stroke before inclusion in the study is no more than 1 month. 4. No severe deficit in cognitive functions. Exclusion Criteria: 1. Patients with implanted ferromagnetic or other metal devices sensitive to a magnetic field in the head or neck area; cochlear implants; implanted neurostimulators, pacemakers, or drug delivery pumps. 2. Complete aphasia or severe cognitive impairment. 3. Taking tricyclic antidepressants, neuroleptics, or benzodiazepines. 4. Previous skull fractures or other head injuries with loss of consciousness. 5. History of epilepsy or seizures. 6. Spasticity of the upper limb (Ashworth scale \>2 b.). 7. Pregnancy
Where this trial is running
Kaunas
- Lithuanian University of Health Sciences — Kaunas, Lithuania (Recruiting)
Study contacts
- Study coordinator: Laura Petrusevičienė, MD
- Email: lciginskaite@gmail.com
- Phone: +37064410732
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.