Effects of resistance training on nervous system function in multiple sclerosis
Effects of Supervised Progressive Resistance Training on Central Nervous System Functioning (Corticospinal Excitability) and Walking Capacity in Persons With Multiple Sclerosis
NA · University of Aarhus · NCT06374108
This study is testing if different levels of resistance training can help improve walking ability and nervous system function in people with multiple sclerosis.
Quick facts
| Phase | NA |
|---|---|
| Study type | Interventional |
| Enrollment | 54 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | University of Aarhus (other) |
| Locations | 2 sites (Aarhus, Central Jutland and 1 other locations) |
| Trial ID | NCT06374108 on ClinicalTrials.gov |
What this trial studies
This study investigates the impact of progressive resistance training on corticospinal excitability and walking capacity in individuals with multiple sclerosis (pwMS). A total of 54 participants will be randomized into three groups: high dose resistance training, low dose resistance training, and a waitlist control group. The study aims to explore how resistance training can improve neuromuscular function and potentially enhance quality of life for pwMS. The methodology includes the use of non-invasive brain stimulation techniques to assess changes in central nervous system functioning.
Who should consider this trial
Good fit: Ideal candidates for this study are adults aged 18 and older with a confirmed diagnosis of multiple sclerosis who experience impairments in walking capacity.
Not a fit: Patients who are pregnant, have other neurological comorbidities, or have participated in structured resistance training recently may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved walking capacity and overall neuromuscular function in patients with multiple sclerosis.
How similar studies have performed: Previous studies have shown positive outcomes with resistance training in improving physical function in multiple sclerosis, suggesting this approach may be effective.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age ≥ 18 years * MS diagnosis according to the McDonald diagnostic criteria * Shows impairments in walking capacity * Ability to self transport to test and exercise Exclusion Criteria: * Pregnancy * Neurological or other comorbidities that affects the nervous system * Relapse within the past 2 months * Pacemaker or metallic implants * Hypertension (medically unregulated) * Participation in structured RT over the past 3 months (≥ 2 sessions/week).
Where this trial is running
Aarhus, Central Jutland and 1 other locations
- Department of Public Health — Aarhus, Central Jutland, Denmark (RECRUITING)
- Department of Nutrition, Exercise and Sports, University of Copenhagen — Copenhagen, Copenhagen N, Denmark (RECRUITING)
Study contacts
- Study coordinator: Lars Hvid, PhD
- Email: lhvid@ph.au.dk
- Phone: 93508717
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Multiple Sclerosis