Effects of resistance training on multiple sclerosis symptoms
Effects of Resistance Training in Multiple Sclerosis: a Randomized Trial. ACTIVE (Physical Activity and Its Impact on Patients With Multiple Sclerosis.)
NA · Hospital Clínico Universitario de Valladolid · NCT06478784
This study is testing if a short-term resistance training program can help improve symptoms and brain health in people with multiple sclerosis compared to those doing moderate aerobic exercise.
Quick facts
| Phase | NA |
|---|---|
| Study type | Interventional |
| Enrollment | 50 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Hospital Clínico Universitario de Valladolid (other) |
| Locations | 1 site (Valladolid) |
| Trial ID | NCT06478784 on ClinicalTrials.gov |
What this trial studies
This study investigates the impact of a short-term resistance training program on biomarkers of neuronal injury in patients with multiple sclerosis. Participants will be divided into two groups: one receiving resistance training and the other undergoing moderate aerobic training. The study will measure changes in plasma levels of neurofilaments and GFAP before and after the intervention, comparing results between the two groups. The goal is to understand how physical exercise influences the progression of multiple sclerosis and to support the integration of exercise into treatment plans.
Who should consider this trial
Good fit: Ideal candidates are adults over 18 years old with a diagnosis of multiple sclerosis, stable clinical condition, and an EDSS score of 4 or lower.
Not a fit: Patients with high levels of physical activity or those with significant comorbidities may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could provide insights into how resistance training may help reduce neuronal injury and improve outcomes for patients with multiple sclerosis.
How similar studies have performed: Previous studies have shown positive effects of physical exercise on multiple sclerosis, but this specific approach focusing on resistance training is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. \- Diagnosis of multiple sclerosis according to the 2017 Mc Donald criteria (Thompson A et al). 2. \- Age \> 18 years - up to no age limit 3. \- Disability assessed by the EDSS (Expanded disability status scale) with a score less than or equal to 4. 4. \- Clinical stability. Not having had an outbreak of the disease in the last 6 months. 5. \- No changes in the disease-modifying treatment in the last 6 months or no treatment. 6. \- Radiological stability. Patients with last MRI (magnetic resonance imaging) performed without inflammatory activity (absence of new lesions on T2 sequences or lesions that enhance with gadolinium). 7. \- They must sign the informed consent Exclusion Criteria: 1. \- Patients with a high level of physical activity according to the International Physical Activity Questionnaire(IPAQ) or latest WHO (World Health Organization) recommendations on physical activity 2. \- Pregnant or breastfeeding patients. 3. \- Concomitant pathologies that limit the performance of physical exercise
Where this trial is running
Valladolid
- Hospital Clínico Universitario de Valladolid — Valladolid, Spain (RECRUITING)
Study contacts
- Principal investigator: Alba Chavarria Miranda, MD — Hospital Clínico Universitario de Valladolid
- Study coordinator: Alba Chavarria Miranda, MD
- Email: achavarria@saludcastillayleon.es
- Phone: 0034983420000
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Multiple Sclerosis, physical exercise, resistance training, neurofilaments, GFAP