Effects of Prucalopride on Gut Recovery After Colorectal Surgery

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the impact of varying doses of prucalopride, a selective serotonin 5-HT4 receptor agonist, on gut function recovery in patients undergoing elective colorectal surgery. It aims to determine whether a higher dose of 4 mg can accelerate bowel function return and reduce hospital stay compared to a standard dose of 2 mg and a placebo. The study addresses the common postoperative complication of ileus, which can delay recovery and prolong hospitalization. By examining the efficacy of different dosing regimens, the research seeks to optimize pharmacological management for postoperative ileus.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* undergoing elective colorectal surgery, including but not limited to colectomy, rectal resection, and sigmoid resection.

Exclusion Criteria:

* Emergency surgery
* Total colectomy
* Creation of a stoma
* Pre-existing gastrointestinal disorders
* Severe renal or hepatic impairment
* Known hypersensitivity to prucalopride.

Where it's running

• Matareya Hospital
  Cairo, Egypt Recruiting

Study contacts

• Study coordinator: Amir Samy Hanna
• Email: amireskanderhanna@gmail.com
• Phone: 01227933624

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.