Effects of preemptive ibuprofen on pain after dental surgery

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial aims to evaluate the impact of preemptive ibuprofen on pain perception and oral health-related quality of life in patients undergoing extraction and bone graft surgery. Participants will be randomly assigned to receive either 600mg of ibuprofen or a placebo one hour before their procedure. Pain levels will be assessed using a Visual Analogue Scale (VAS) at various time points post-surgery, and quality of life will be measured using the Oral Health Impact Profile-14 (OHIP-14) questionnaire. The study seeks to determine if preemptive ibuprofen can effectively reduce postoperative pain and improve recovery outcomes compared to a placebo.

Why it matters

Who can join: the full rules

Inclusion Criteria

* Age \>18 years
* Good general health (controlled conditions)
* Fluent in English
* Treatment-planned for single site extraction and bone graft surgery

Exclusion criteria

* Pregnancy
* Site with active infection i.e purulence, abscess formation
* Patients experiencing pain pre-operatively
* Oral surgery in more than one site/quadrant in the same session
* Patients receiving surgery under sedation
* Patients with any contraindication for oral bone grafting surgery (e.g., on anticoagulants, medication-related osteonecrosis of the jaw, etc.)
* Patients experiencing acute or chronic oral pain due to conditions or previous interventions
* Patients with diseases or taking medications that affect hard and soft tissue wound healing such as poorly controlled diabetes, bisphosphonate use, corticosteroid use, chemotherapy, immunosuppressive therapy, etc.
* Current or chronic (≥4 weeks) use of anti-inflammatory, analgesic, corticosteroid or sedative medications in the past 6 months
* Health conditions that contraindicate the use of NSAIDs, such as stomach ulcers, bleeding disorders, renal disfunction, liver cirrhosis or acute liver disease, etc.
* Intake of medications that interact with NSAIDs or whose actions can be affected by NSAIDs, such as anticoagulant/antiplatelet medications, ACE inhibitors, diuretics, etc.
* Allergy to ibuprofen, acetaminophen and/or aspirin, and study materials (e.g., sutures, grafts, membranes?).
* Patients having 3 or more alcoholic beverages daily
* Patients who are planned to undergo heart surgery or had heart surgery less than 6 months prior
* Not fluent in English

Where it's running

• Marquette University School of Dentistry Graduate Periodontics Clinic
  Milwaukee, Wisconsin, United States Recruiting

Study contacts

• Principal investigator: Vrisiis Kofina, DDS, MS — Marquette University
• Study coordinator: Vrisiis Kofina, DDS, MS
• Email: vrisiis.kofina@marquette.edu
• Phone: 516-817-0393

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Comparing pain relief options for children after surgery

  This study tests which pain relief method works better for kids recovering from surgery: a mix of common pain relievers or a low dose of opioids with those pain relievers.

  Recruiting at 4 sites Phase 4 University of Michigan · Phoenix, Arizona and 8 other locations · NCT06671002

• Reducing post-mastectomy pain with opioid-free anesthesia

  This study is testing whether using anesthesia without opioids can help women who have had a mastectomy experience less chronic pain a year after their surgery compared to traditional opioid-based anesthesia.

  Recruiting Gangnam Severance Hospital · Seoul · NCT05146778

• Magnesium given during colorectal cancer surgery to see if it lowers inflammation afterward

  We’re testing whether giving magnesium sulfate during open colorectal cancer surgery can reduce postoperative inflammation in patients.

  Recruiting Ain Shams University · Cairo, Abbassia · NCT07803601

• Novel nanoparticle-enhanced disinfection for post-operative tooth pain

  A new nanoparticle-based disinfection method is being tested to see if it reduces pain after root canal treatment in adults with certain tooth infections.

  Recruiting Minia University · Minya · NCT07800403

• Oral tizanidine before surgery to calm pain after leg surgery

  This trial tests whether giving a preoperative dose of oral tizanidine helps reduce postoperative pain and improve sleep quality for adults undergoing lower limb orthopedic surgery.

  Recruiting Tanta University · Tanta, Gharbia Governorate · NCT07800364

• Influence of Irrigant Delivery Methods on Postoperative Pain after Root Canal Treatment in Oval Canals

  This trial tests whether different irrigant delivery and activation methods affect postoperative pain after primary root canal treatment in adults.

  Recruiting Minia University · Minya · NCT07788027

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.