Effects of preemptive ibuprofen on pain after dental surgery
Patient Perception of Pain Following Extraction and Bone Graft Surgery With or Without Preemptive Ibuprofen: A Randomized Clinical Trial
This study is testing if taking ibuprofen before dental surgery can help reduce pain and improve recovery for patients getting their teeth extracted or having bone grafts.
Quick facts
| Phase | Phase 4 |
|---|---|
| Study type | Interventional |
| Enrollment | 50 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Marquette University Academic / other |
| Drugs / interventions | chemotherapy |
| Locations | 1 site (Milwaukee, Wisconsin) |
| Trial ID | NCT05919745 on ClinicalTrials.gov |
What this trial studies
This clinical trial aims to evaluate the impact of preemptive ibuprofen on pain perception and oral health-related quality of life in patients undergoing extraction and bone graft surgery. Participants will be randomly assigned to receive either 600mg of ibuprofen or a placebo one hour before their procedure. Pain levels will be assessed using a Visual Analogue Scale (VAS) at various time points post-surgery, and quality of life will be measured using the Oral Health Impact Profile-14 (OHIP-14) questionnaire. The study seeks to determine if preemptive ibuprofen can effectively reduce postoperative pain and improve recovery outcomes compared to a placebo.
Who should consider this trial
Good fit: Ideal candidates are adults over 18 years old in good general health who are scheduled for single site extraction and bone graft surgery.
Not a fit: Patients with active infections, those experiencing pre-operative pain, or individuals with contraindications for oral surgery may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved pain management strategies for patients undergoing dental surgeries.
How similar studies have performed: Previous studies have shown that preemptive analgesia can be effective in managing postoperative pain, suggesting potential success for this approach.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria * Age \>18 years * Good general health (controlled conditions) * Fluent in English * Treatment-planned for single site extraction and bone graft surgery Exclusion criteria * Pregnancy * Site with active infection i.e purulence, abscess formation * Patients experiencing pain pre-operatively * Oral surgery in more than one site/quadrant in the same session * Patients receiving surgery under sedation * Patients with any contraindication for oral bone grafting surgery (e.g., on anticoagulants, medication-related osteonecrosis of the jaw, etc.) * Patients experiencing acute or chronic oral pain due to conditions or previous interventions * Patients with diseases or taking medications that affect hard and soft tissue wound healing such as poorly controlled diabetes, bisphosphonate use, corticosteroid use, chemotherapy, immunosuppressive therapy, etc. * Current or chronic (≥4 weeks) use of anti-inflammatory, analgesic, corticosteroid or sedative medications in the past 6 months * Health conditions that contraindicate the use of NSAIDs, such as stomach ulcers, bleeding disorders, renal disfunction, liver cirrhosis or acute liver disease, etc. * Intake of medications that interact with NSAIDs or whose actions can be affected by NSAIDs, such as anticoagulant/antiplatelet medications, ACE inhibitors, diuretics, etc. * Allergy to ibuprofen, acetaminophen and/or aspirin, and study materials (e.g., sutures, grafts, membranes?). * Patients having 3 or more alcoholic beverages daily * Patients who are planned to undergo heart surgery or had heart surgery less than 6 months prior * Not fluent in English
Where this trial is running
Milwaukee, Wisconsin
- Marquette University School of Dentistry Graduate Periodontics Clinic — Milwaukee, Wisconsin, United States (Recruiting)
Study contacts
- Principal investigator: Vrisiis Kofina, DDS, MS — Marquette University
- Study coordinator: Vrisiis Kofina, DDS, MS
- Email: vrisiis.kofina@marquette.edu
- Phone: 516-817-0393
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.