Effects of Platelet-rich Fibrin and Vitamin D3 Injections on Gum Health

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study evaluates the impact of platelet-rich fibrin (PRF) and vitamin D3 injections on periodontal health during orthodontic treatment. Participants will be randomly assigned to receive either PRF or vitamin D3 injections on one side of their mouth, while the opposite side will serve as a control. The study aims to assess the effectiveness of these interventions in improving periodontal parameters. A total of 28 participants aged 18-40 with specific dental malocclusions will be recruited from the Faculty of Dentistry at Beni-Suef University.

Why it matters

Who can join: the full rules

Inclusion criteria:

1. Age: 18- 40 years old.
2. Angle Class I or Class II dental malocclusion that required bilateral maxillary first premolar extraction and upper canine retraction as a part of the treatment plan.
3. Good to fair oral hygiene.
4. Normal probing depth.

Exclusion criteria:

1. Active periodontal disease.
2. Poor oral hygiene.
3. Systemic diseases or medications that alter bone metabolism or tooth movement.
4. Craniofacial anomalies.

Where it's running

• Faculty of Dentistry Beni Suef University
  Banī Suwayf, Egypt Recruiting

Study contacts

• Principal investigator: Rehab Khalil — Faculty of Dentistry Beni Suef University
• Study coordinator: Rehab Khalil
• Email: rehababdelrazek@dent.bsu.edu.eg
• Phone: 01005230669

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.