Effects of Platelet-rich Fibrin and Vitamin D3 Injections on Gum Health
Evaluation of the Effects of Platelet-rich Fibrin and Vitamin Dꝫ Injections on the Periodontal Health During Canine Distalization: A Randomized Controlled Clinical Trial
This study is testing whether injections of platelet-rich fibrin or vitamin D3 can improve gum health for people getting braces.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 14 (estimated) |
| Ages | 18 Years to 40 Years |
| Sex | All |
| Sponsor | Beni-Suef University Academic / other |
| Locations | 1 site (Banī Suwayf) |
| Trial ID | NCT06223477 on ClinicalTrials.gov |
What this trial studies
This study evaluates the impact of platelet-rich fibrin (PRF) and vitamin D3 injections on periodontal health during orthodontic treatment. Participants will be randomly assigned to receive either PRF or vitamin D3 injections on one side of their mouth, while the opposite side will serve as a control. The study aims to assess the effectiveness of these interventions in improving periodontal parameters. A total of 28 participants aged 18-40 with specific dental malocclusions will be recruited from the Faculty of Dentistry at Beni-Suef University.
Who should consider this trial
Good fit: Ideal candidates are individuals aged 18-40 with Angle Class I or II dental malocclusion requiring upper canine retraction.
Not a fit: Patients with active periodontal disease, poor oral hygiene, or systemic conditions affecting bone metabolism will not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could enhance periodontal health and improve orthodontic outcomes for patients.
How similar studies have performed: While the use of PRF in dental treatments has shown promise, the specific combination of PRF and vitamin D3 for periodontal health in orthodontics is relatively novel and has not been extensively tested.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion criteria: 1. Age: 18- 40 years old. 2. Angle Class I or Class II dental malocclusion that required bilateral maxillary first premolar extraction and upper canine retraction as a part of the treatment plan. 3. Good to fair oral hygiene. 4. Normal probing depth. Exclusion criteria: 1. Active periodontal disease. 2. Poor oral hygiene. 3. Systemic diseases or medications that alter bone metabolism or tooth movement. 4. Craniofacial anomalies.
Where this trial is running
Banī Suwayf
- Faculty of Dentistry Beni Suef University — Banī Suwayf, Egypt (Recruiting)
Study contacts
- Principal investigator: Rehab Khalil — Faculty of Dentistry Beni Suef University
- Study coordinator: Rehab Khalil
- Email: rehababdelrazek@dent.bsu.edu.eg
- Phone: 01005230669
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.