Effects of oxygen therapy on decompression sickness in divers
Impact of Hyperoxia and Involvement of the Immune System in Diving Accident
This study tests if oxygen therapy can help treat decompression sickness in divers by looking at how different oxygen levels affect their recovery.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 265 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Direction Centrale du Service de Santé des Armées Academic / other |
| Locations | 1 site (Toulon) |
| Trial ID | NCT04791488 on ClinicalTrials.gov |
What this trial studies
This study investigates the impact of hyperoxia and the immune system's role in decompression sickness, particularly focusing on the effects of hyperbaric oxygen therapy. It aims to understand how oxygen levels influence the development of decompression sickness during diving and the subsequent treatment with normobaric and hyperbaric oxygen. The research involves healthy subjects and patients suspected of diving accidents, utilizing diving simulations to assess the physiological responses. The study will analyze circulating mitochondrial DNA levels to explore cellular damage associated with hyperoxia.
Who should consider this trial
Good fit: Ideal candidates include healthy individuals without diving contraindications or patients suspected of having experienced a diving accident.
Not a fit: Patients with contraindications to diving or hyperbaric oxygen therapy will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could improve treatment protocols for decompression sickness, enhancing recovery outcomes for divers.
How similar studies have performed: Previous studies have shown varying effects of oxygen therapy in similar contexts, indicating both potential benefits and risks, making this investigation relevant and timely.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Healthy subject with no contraindications to diving OR patient admitted to the hospital for suspicion of a diving accident OR patient admitted to the hospital for hyperbaric oxygen therapy Exclusion Criteria: * Contraindication to diving or contraindication to hyperbaric oxygen therapy
Where this trial is running
Toulon
- Hôpital d'Instruction des Armées Sainte-Anne — Toulon, France (Recruiting)
Study contacts
- Study coordinator: Nicolas VALLEE, PhD
- Email: nicolas.vallee@intradef.gouv.fr
- Phone: 483162849
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.