Effects of oxygen levels on lung complications after esophageal cancer surgery

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates how different concentrations of oxygen during mechanical ventilation affect the occurrence of pulmonary complications in patients undergoing radical resection of esophageal cancer. It aims to determine whether using lower oxygen concentrations (30%) compared to standard levels (60%) can maintain adequate oxygen saturation while reducing postoperative complications. The study will involve patients with specific health conditions scheduled for elective surgery, and it will monitor their postoperative outcomes related to lung health. The findings could provide insights into optimal ventilation strategies for this patient population.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* American Association of Anesthesiologists (ASA) patients with I-II physical condition;
* Patients with preoperative partial pressure of blood gas and oxygen greater than 80mmHg who were scheduled for elective esophageal cancer surgery were operated in the right lateral position first and then in the supine position.

Exclusion Criteria:

* there is a history of acute lung injury with acute respiratory distress syndrome within three months;
* Heart failure (classified by new york Heart Association) is greater than grade IV,
* there is a serious liver and kidney dysfunction (children with grade B or C liver failure, glomerular filtration rate \< 30 ml/min);
* Body mass index \> 30kg/m2；
* coagulation dysfunction;
* Operation time exceeds 10h
* The amount of bleeding is more than 800ml, and the total fluid volume is more than 3000ml.

Where it's running

• the First Hospital of China Medical University
  Shenyang, Liaoning, China Recruiting

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.