Effects of oral probiotics on vaginal health in women with vaginitis and HPV
The Influence of Oral Probiotic on the Vaginal Flora and Microenvironment Alteration in the Vaginosis Infection Women
This study is testing if taking a specific probiotic can help improve vaginal health in women who have vaginitis and HPV.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 76 (estimated) |
| Ages | 20 Years to 75 Years |
| Sex | Female |
| Sponsor | Chang Gung Memorial Hospital Academic / other |
| Locations | 1 site (Kaohsiung) |
| Trial ID | NCT06001190 on ClinicalTrials.gov |
What this trial studies
This clinical trial investigates the impact of oral probiotics, specifically Lactobacillus crispatus, on the vaginal flora and microenvironment in adult women diagnosed with vaginitis and/or HPV positive. Participants will receive probiotic treatment and undergo regular follow-up with cervical swabs to monitor changes in their vaginal microbiome throughout the study. The study is designed as a single-blind, randomized intervention to assess the efficacy of probiotics in improving vaginal health.
Who should consider this trial
Good fit: Ideal candidates for this study are adult women diagnosed with vaginitis and who are HPV positive.
Not a fit: Patients who are pregnant, virgins, or have severe cervical pathology or confirmed cervical cancer may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could provide a novel treatment option for women suffering from vaginitis and HPV-related issues.
How similar studies have performed: While the use of probiotics in vaginal health is an emerging area, this specific approach has not been extensively tested in prior studies, making it a novel investigation.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * diagnosed as vaginal viginitis * willing to sign permit * willing to regular follow up Exclusion Criteria: * Pregnant * Virgin * Severe cervix pathology CINII or CIN III * Confirmed cervical cancer * under long term antibiotics due to other physical condition
Where this trial is running
Kaohsiung
- Kaohsiung Chang Gung Memorial Hospital — Kaohsiung, Taiwan (Recruiting)
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.