Effects of one week of fasting on metabolism and immunity in humans

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the impact of a one-week fasting period, allowing water intake, on human immune function, metabolic indicators, and brain function. It aims to explore the underlying mechanisms of these changes through a multi-omics approach. The research builds on previous findings that suggest fasting can enhance cellular autophagy, improve insulin sensitivity, and reduce inflammation, potentially benefiting metabolic health and cognitive function. By focusing on human subjects, this study seeks to fill the gap left by prior animal studies and provide new insights into the biological mechanisms involved in fasting.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Age 18-65 years old, gender is not limited;
2. BMI≥18.5;
3. Can tolerate a certain degree of hunger;
4. Can voluntarily sign written informed consent.

Exclusion Criteria:

1. Women planning pregnancy, pregnancy and breastfeeding;
2. Previous liver disease, chronic kidney disease, heart disease and cerebrovascular disease;
3. Suffering from acute infectious diseases or chronic wasting diseases;
4. Have used antibiotic drugs in the past 3 months, and have used prebiotic or probiotic supplements or products in the past month;
5. Participate in other clinical investigators within 3 months before enrollment in this study.

Where it's running

• Xuanwu Hospital, Capital Medical University
  Beijing, China Recruiting

Study contacts

• Principal investigator: Hongxing Wang, MD & PhD — Xuanwu Hospital, Beijing
• Study coordinator: Rui Li, MD
• Email: ruili@mail.ccmu.edu.cn
• Phone: +86 10 83198650

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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• Fasting versus continuing tube feeding before procedures for critically ill patients

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• Effects of a 48-hour fast with or without exercise on immune function and blood sugar control

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  Recruiting University of British Columbia · Kelowna, British Columbia · NCT06737224

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.