Effects of Omega-3 Fatty Acids on Brain Health in Soccer Players

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This double-blind, randomized placebo-controlled trial aims to investigate the impact of omega-3 fatty acids, specifically DHA and EPA, on brain health in adult soccer players aged 18-30 who experience subconcussive head impacts. Participants will receive either omega-3 supplementation or a placebo while undergoing assessments including questionnaires, blood draws, brain imaging, and heart function tests. The study also includes a sub-cohort of participants diagnosed with ADHD for exploratory analyses. The goal is to determine how omega-3 supplementation may enhance neural resilience against repetitive head impacts.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Between age 18-30
* Current or former soccer player
* At least 5 years of soccer heading experience
* Have internet access
* Willing to commit to avoid any sport activity that purposefully uses one's head to maneuver during the study period (American football, ice-hockey, rugby, wrestling, and soccer heading).

Exclusion Criteria:

* Any head or neck injury within 6 months before the study
* Implanted metal/magnetic devices (e.g., orthodontic braces
* Diagnosed autonomic or cardiovascular diseases (e.g., hypertension)
* Consuming oily fish (2 servings or more/month: salmon, bluefin, swordfish, anchovies)
* Allergy to fish or shellfish
* Consuming omega-3 FA supplements including plant-based (e.g., flaxseed) in the past 3 months.
* Pregnancy

Where it's running

• Indiana University School of Public Health
  Bloomington, Indiana, United States Recruiting

Study contacts

• Study coordinator: Kei Kawata
• Email: kkawata@indiana.edu
• Phone: 812-855-5244

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.