Effects of nitrogen pollution on pollen allergies in Belgium
Impacts of Nitrogen Deposition in the Natural Environment on Pollen Allergy in Belgium
This study is testing how nitrogen pollution affects allergy symptoms in people who are sensitive to pollen in Belgium.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 200 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Universitaire Ziekenhuizen KU Leuven Academic / other |
| Locations | 1 site (Leuven, Vlaams-Brabant) |
| Trial ID | NCT06714149 on ClinicalTrials.gov |
What this trial studies
This study investigates how nitrogen enrichment in the environment affects allergy symptoms in individuals sensitized to pollen. It involves analyzing allergen-specific IgE reactivity in pollen-allergic patients and comparing their responses to various pollen samples. The study will assess basophil degranulation thresholds and the qualitative and quantitative reactivity to different pollen fragments. Additionally, it aims to correlate allergy symptoms with the reactivity to these pollen samples.
Who should consider this trial
Good fit: Ideal candidates are individuals with a positive skin prick test for grass and/or birch pollen.
Not a fit: Patients who have undergone desensitization therapy in the last two years may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved understanding and management of pollen allergies in relation to environmental factors.
How similar studies have performed: While studies on environmental impacts on allergies exist, this specific focus on nitrogen deposition and its direct effects on pollen allergy is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Positive skin prick test for grass and/or birch pollen Exclusion Criteria: * Desensitization therapy during the last two years
Where this trial is running
Leuven, Vlaams-Brabant
- University Hospitals Leuven — Leuven, Vlaams-Brabant, Belgium (Recruiting)
Study contacts
- Study coordinator: Rik Schrijvers, MD, PhD
- Email: rik.schrijvers@uzleuven.be
- Phone: +3216342985
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.